Histological evaluation of thyroid carcinomas: Reproducibility of the 'WHO' classification

A. S. Fassina, M. C. Montesco, V. Ninfo, P. Denti, G. Masarotto

Research output: Contribution to journalArticle

Abstract

Aims and Background: Thyroid carcinomas display several pathologic features, show different behavior and necessitate different treatment; thus correct classification is mandatory. Methods: The kappa statistic was used as a measure of agreement in a panel of seven pathologists who reviewed 200 cases of thyroid tumors. Results: Overall agreement was 83% (k = 68). Good agreement was found for anaplastic (k = 0.85) and papillary carcinomas (k = 0.81); agreement for medullary carcinoma was acceptable (k = 0.80), suboptimal for other (k = 0.67), and poor for follicular carcinoma (k = 0.54). Conclusions: Central pathology review of thyroid carcinomas is recommended when clinical and epidemiologic trials are planned.

Original languageEnglish
Pages (from-to)314-320
Number of pages7
JournalTumori
Volume79
Issue number5
Publication statusPublished - 1993

Keywords

  • interobserver reproducibility
  • kappa statistic
  • thyroid carcinomas

ASJC Scopus subject areas

  • Cancer Research

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    Fassina, A. S., Montesco, M. C., Ninfo, V., Denti, P., & Masarotto, G. (1993). Histological evaluation of thyroid carcinomas: Reproducibility of the 'WHO' classification. Tumori, 79(5), 314-320.