Histological features of extratumoral breast lesions as a predictive factor of familial breast cancer

Anita Mangia, Stefania Tommasi, Michele Bruno, Andrea Malfettone, Cosimo D'Amico, Francesco Alfredo Zito, Angelo Paradiso, Giovanni Simone

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to verify whether histopathological features of extratumoral and of primary tumor breast tissue could play a role in identifying patients with familial characteristics. We examined the clinicopathological features of 504 patients with sporadic or familial breast cancer stratified for risk of BRCA mutation. Patients with a higher risk of being carrier of BRCA gene mutations were significantly associated with tumor poor differentiation (p=0.003), positive lymph node invasion (p=0.02) and presence of vascular peritumoral invasion (p=0.008). Among the extra-tumoral lesions, only the epithelial proliferative lesions were related to higher mutation risk both in the overall series and familial patients (p

Original languageEnglish
Pages (from-to)1641-1645
Number of pages5
JournalOncology Reports
Volume23
Issue number6
DOIs
Publication statusPublished - 2010

Keywords

  • BRCA genes risk mutation
  • Extratumoral breast lesions
  • UDH
  • Vascular peritumoral invasion

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

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