Histological findings in foetuses congenitally infected by cytomegalovirus

Liliana Gabrielli, Maria Paola Bonasoni, Tiziana Lazzarotto, Stefania Lega, Donatella Santini, Maria Pia Foschini, Brunella Guerra, Federica Baccolini, Giulia Piccirilli, Angela Chiereghin, Evangelia Petrisli, Giorgio Gardini, Marcello Lanari, Maria Paola Landini

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Background: Congenital cytomegalovirus (CMV) infection is a major cause of central nervous system damage leading to sensorineural hearing loss, mental retardation and cerebral palsy. Objectives: Identify the type of organ involvement and understand the histopathogenesis of damage in foetuses of women with a CMV-highly positive amniotic fluid. Study design: 34 foetuses with congenital CMV infection documented by prenatal diagnosis were studied. Three foetuses died in utero. The remaining pregnancies were electively terminated at 20-21 weeks gestation. Results: Foetal organs positive for CMV antigens were: placenta (100%), pancreas (100%), lung (87%), kidney (87%), liver (71%), brain (55%) and heart (44%). Inflammatory infiltrate was almost always present in CMV-infected foetal organs and the severity of the inflammatory response was correlated with the organ damage. Brain damage with necrosis was observed in 33% (9/27) and a mild telencephalic leukoencephalopathy in 22% (6/27) of foetuses studied. Conclusions: Focal necrosis was observed very frequently in organs such as pancreases, livers, hearts and kidneys. However the damage in these organs is likely to be resolved by parenchymal regeneration. Brain damage, which seems to be the results of a combined effect of viral infection, inflammatory infiltration and hypoxia due to severe placentitis, is less likely to be resolved because of the low regeneration ability of this organ.

Original languageEnglish
JournalJournal of Clinical Virology
Volume46
Issue numberSUPPL. 4
DOIs
Publication statusPublished - Dec 2009

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Cytomegalovirus
Fetus
Cytomegalovirus Infections
Regeneration
Pancreas
Brain
Necrosis
Kidney
Pregnancy
Aptitude
Sensorineural Hearing Loss
Liver
Virus Diseases
Cerebral Palsy
Amniotic Fluid
Prenatal Diagnosis
Intellectual Disability
Placenta
Central Nervous System
Antigens

Keywords

  • Brain damage
  • Congenital infection
  • Cytomegalovirus
  • Foetuses
  • Inflammatory infiltration
  • Placenta

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Gabrielli, L., Bonasoni, M. P., Lazzarotto, T., Lega, S., Santini, D., Foschini, M. P., ... Landini, M. P. (2009). Histological findings in foetuses congenitally infected by cytomegalovirus. Journal of Clinical Virology, 46(SUPPL. 4). https://doi.org/10.1016/j.jcv.2009.09.026

Histological findings in foetuses congenitally infected by cytomegalovirus. / Gabrielli, Liliana; Bonasoni, Maria Paola; Lazzarotto, Tiziana; Lega, Stefania; Santini, Donatella; Foschini, Maria Pia; Guerra, Brunella; Baccolini, Federica; Piccirilli, Giulia; Chiereghin, Angela; Petrisli, Evangelia; Gardini, Giorgio; Lanari, Marcello; Landini, Maria Paola.

In: Journal of Clinical Virology, Vol. 46, No. SUPPL. 4, 12.2009.

Research output: Contribution to journalArticle

Gabrielli, L, Bonasoni, MP, Lazzarotto, T, Lega, S, Santini, D, Foschini, MP, Guerra, B, Baccolini, F, Piccirilli, G, Chiereghin, A, Petrisli, E, Gardini, G, Lanari, M & Landini, MP 2009, 'Histological findings in foetuses congenitally infected by cytomegalovirus', Journal of Clinical Virology, vol. 46, no. SUPPL. 4. https://doi.org/10.1016/j.jcv.2009.09.026
Gabrielli L, Bonasoni MP, Lazzarotto T, Lega S, Santini D, Foschini MP et al. Histological findings in foetuses congenitally infected by cytomegalovirus. Journal of Clinical Virology. 2009 Dec;46(SUPPL. 4). https://doi.org/10.1016/j.jcv.2009.09.026
Gabrielli, Liliana ; Bonasoni, Maria Paola ; Lazzarotto, Tiziana ; Lega, Stefania ; Santini, Donatella ; Foschini, Maria Pia ; Guerra, Brunella ; Baccolini, Federica ; Piccirilli, Giulia ; Chiereghin, Angela ; Petrisli, Evangelia ; Gardini, Giorgio ; Lanari, Marcello ; Landini, Maria Paola. / Histological findings in foetuses congenitally infected by cytomegalovirus. In: Journal of Clinical Virology. 2009 ; Vol. 46, No. SUPPL. 4.
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AU - Santini, Donatella

AU - Foschini, Maria Pia

AU - Guerra, Brunella

AU - Baccolini, Federica

AU - Piccirilli, Giulia

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AU - Petrisli, Evangelia

AU - Gardini, Giorgio

AU - Lanari, Marcello

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