TY - JOUR
T1 - Histological recurrent hepatitis C after liver transplantation
T2 - Outcome and role of retransplantation
AU - Ercolani, Giorgio
AU - Grazi, Gian Luca
AU - Ravaioli, Matteo
AU - Del Gaudio, Massimo
AU - Cescon, Matteo
AU - Lauro, Augusto
AU - Varotti, Giovanni
AU - Ramacciato, Giovanni
AU - Vetrone, Gaetano
AU - Zanello, Matteo
AU - Pinna, Antonio Daniele
PY - 2006/7
Y1 - 2006/7
N2 - Impact of hepatitis C virus (HCV) recurrence on long-term outcome after orthotopic liver transplantation (OLT) is highly variable, and the role of retransplantation is still debated. From 1996 to 2003, 131 OLT with histologically proven HCV recurrence and 6 months of follow-up were retrospectively reviewed. One and 5-yr overall survivals were 90.7 and 81.3%, respectively. The mean time of HCV recurrence was 10.1 ± 6.2 months in patients whose donor's age was less than 70 yr old, and 6.6 ± 4.7 in patients whose donor's age was more than 70 (P <0.01). The mean time between OLT and HCV recurrence was 10.7 ± 8.2 months among patients still alive, and 5 ± 4.2 among the 20 who died (P = 0.02). In 16 (12.2%) patients, retransplantation was required for severe HCV recurrence; 5 are still alive and 11 (68.7%) died. The mean survival time was 16.2 ± 6 months if re-OLT was performed within 12 months from first OLT, and it was 45.9 ± 10 months if re-OLT was performed later (P <0.01). In conclusion, donors older than 70 yr are at high risk of early HCV recurrence; expectancy of life is significantly reduced in case of histologically proven recurrence within 6 months. Outcome is quite dismal in patients with early HCV recurrence requiring retransplantation within 1 yr of first OLT.
AB - Impact of hepatitis C virus (HCV) recurrence on long-term outcome after orthotopic liver transplantation (OLT) is highly variable, and the role of retransplantation is still debated. From 1996 to 2003, 131 OLT with histologically proven HCV recurrence and 6 months of follow-up were retrospectively reviewed. One and 5-yr overall survivals were 90.7 and 81.3%, respectively. The mean time of HCV recurrence was 10.1 ± 6.2 months in patients whose donor's age was less than 70 yr old, and 6.6 ± 4.7 in patients whose donor's age was more than 70 (P <0.01). The mean time between OLT and HCV recurrence was 10.7 ± 8.2 months among patients still alive, and 5 ± 4.2 among the 20 who died (P = 0.02). In 16 (12.2%) patients, retransplantation was required for severe HCV recurrence; 5 are still alive and 11 (68.7%) died. The mean survival time was 16.2 ± 6 months if re-OLT was performed within 12 months from first OLT, and it was 45.9 ± 10 months if re-OLT was performed later (P <0.01). In conclusion, donors older than 70 yr are at high risk of early HCV recurrence; expectancy of life is significantly reduced in case of histologically proven recurrence within 6 months. Outcome is quite dismal in patients with early HCV recurrence requiring retransplantation within 1 yr of first OLT.
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U2 - 10.1002/lt.20725
DO - 10.1002/lt.20725
M3 - Article
C2 - 16710855
AN - SCOPUS:33746025666
VL - 12
SP - 1104
EP - 1111
JO - Liver Transplantation
JF - Liver Transplantation
SN - 1527-6465
IS - 7
ER -