Histological recurrent hepatitis C after liver transplantation: Outcome and role of retransplantation

Giorgio Ercolani, Gian Luca Grazi, Matteo Ravaioli, Massimo Del Gaudio, Matteo Cescon, Augusto Lauro, Giovanni Varotti, Giovanni Ramacciato, Gaetano Vetrone, Matteo Zanello, Antonio Daniele Pinna

Research output: Contribution to journalArticlepeer-review

Abstract

Impact of hepatitis C virus (HCV) recurrence on long-term outcome after orthotopic liver transplantation (OLT) is highly variable, and the role of retransplantation is still debated. From 1996 to 2003, 131 OLT with histologically proven HCV recurrence and 6 months of follow-up were retrospectively reviewed. One and 5-yr overall survivals were 90.7 and 81.3%, respectively. The mean time of HCV recurrence was 10.1 ± 6.2 months in patients whose donor's age was less than 70 yr old, and 6.6 ± 4.7 in patients whose donor's age was more than 70 (P <0.01). The mean time between OLT and HCV recurrence was 10.7 ± 8.2 months among patients still alive, and 5 ± 4.2 among the 20 who died (P = 0.02). In 16 (12.2%) patients, retransplantation was required for severe HCV recurrence; 5 are still alive and 11 (68.7%) died. The mean survival time was 16.2 ± 6 months if re-OLT was performed within 12 months from first OLT, and it was 45.9 ± 10 months if re-OLT was performed later (P <0.01). In conclusion, donors older than 70 yr are at high risk of early HCV recurrence; expectancy of life is significantly reduced in case of histologically proven recurrence within 6 months. Outcome is quite dismal in patients with early HCV recurrence requiring retransplantation within 1 yr of first OLT.

Original languageEnglish
Pages (from-to)1104-1111
Number of pages8
JournalLiver Transplantation
Volume12
Issue number7
DOIs
Publication statusPublished - Jul 2006

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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