Histological substrate of atrial biopsies in patients with lone atrial fibrillation

Andrea Frustaci, Cristina Chimenti, Fulvio Bellocci, Emanuela Morgante, Matteo A. Russo, Attilio Maseri

Research output: Contribution to journalArticle

Abstract

Background: Lone atrial fibrillation (LAF) is a common clinical syndrome, but its origin remains unknown. Methods and Results: We performed endomyocardial biopsies of the right atrial septum (2 to 3 per patient; mean, 2.8) and of the two ventricles (6 per patient) in 12 patients (10 men, 2 women; mean age, 32 years) with paroxysmal LAF refractory to conventional antiarrhythmic treatment. As controls, we used endomyocardial biopsies (3 to 5 per patient; mean, 4.4) from the right atrial septum of 11 patients with Wolff-Parkinson-White syndrome (WPW) undergoing resection of the abnormal AV pathway. The weight of the biopsies ranged from 2.8 to 4.5 mg. Biopsy samples were processed for histology and electron microscopy and were read by a pathologist blinded to clinical data. All patients underwent two-dimensional Doppler echocardiography; cardiac catheterization; coronary angiography; and hormonal, virologic, and electrophysiological studies. All tests and WPW biopsies were normal, but all LAF atrial biopsy specimens (average, 2.8 per patient) showed abnormalities (P50% of the areas assessed morphometrically (P=.50), 8 had lymphomononuclear infiltrates with necrosis of the adjacent myocytes (5 with fibrosis and 3 without; P

Original languageEnglish
Pages (from-to)1180-1184
Number of pages5
JournalCirculation
Volume96
Issue number4
Publication statusPublished - Aug 19 1997

Keywords

  • Biopsy
  • Fibrillation
  • Pathology

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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