Histomorphic-metric evaluation of an implant retrieved from human maxilla after 13 years

T. Traini, M. Danza, R. Altavilla, I. Zollino, A. Lucchese, V. Sollazzo, G. Trapella, G. Brunelli, Francesco Carinci

Research output: Contribution to journalArticlepeer-review


Fixture fracture is the most catastrophic failure of implant components because it usually causes the loss of the implant. Nevertheless, the osseointegrated fractured implants represent a very useful opportunity to study in humans the effects of loading to the peri-implant bone microstructure. The aim of the present study was to evaluate the interplay between microstructure and function of the bone around an implant retrieved from human maxilla after 13 years. There was 1 fractured Dental Implant Line (sand blasted surface from a patient placed in the anterior region of the maxillary bone (2.1) after a bone augmentation procedure, and it was processed for histology. The specimen was analyzed under the scanning electron microscope (SEM), the confocal scanning laser microscope (CSLM) and brightfield light microscope (LM) equipped with circularly polarized light (CPL). The BIC rate of the implant retrieved after 13 years was (mean ±SD) 68.7 ± 3.7. The crestal bone down the implant platform damage appeared to be under modeling process. The transverse collagen fiber orientation (CFO) (mean ±SD) under the lower flank of the threads was 20.4 ± 3.5 × 104 pixel while the longitudinal CFO was 19.8 ± 2.8 × 104 pixel (P>.05). In the inter-threads region the transverse CFO (mean ±SD) was 15.0 ± 4.0 × 104 pixel while the longitudiual CFO was 21.4 ± 3.0 × 104 pixel (P>.05). The osteocytes numbers (mean ±SD) was 130 ± 34. Under SEM with back scattered electrons (BSE) signal the peri-implant bone appears mainly lamellar and highly mature with several osteons organized in the implant inter-threads areas. The fracture of the implant was most probably correlated to a fatigue of the material mainly associated to a damage of the internal coil. Surprisingly, it was noted a lack of implant site-specific CFO of the bone extracellular matrix facing the threaded dental implant notwithstanding the high level of BIC rate.

Original languageEnglish
Pages (from-to)25-30
Number of pages6
JournalInternational Journal of Immunopathology and Pharmacology
Issue numberSUPPL. 2
Publication statusPublished - 2011


  • Bone implant contact rate
  • Circularly polarized light microscopy
  • Collagen fiber orientation
  • Dental implant line
  • Implant fracture

ASJC Scopus subject areas

  • Pharmacology
  • Immunology
  • Immunology and Allergy


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