Histomorphometric outcomes after lateral sinus floor elevation procedure

a systematic review of the literature and meta-analysis

Research output: Contribution to journalReview article

Abstract

Objectives: The aim of the present systematic review of the literature was to evaluate biomaterials performances considering new bone formation estimated through histomorphometric analysis of bone biopsies from human subjects after maxillary sinus floor elevation. Materials and methods: An electronic and manual search was performed to retrieve articles showing histomorphometric data of bone biopsies performed after sinus floor elevation surgery. Recorded data were statistically analyzed evaluating percentage of new bone volume, residual biomaterial, and connective/soft tissues in the biopsies. A meta-analysis of comparative studies was also performed. Results: After article selection process, 84 articles were included in the quantitative synthesis and 16 of them in the meta-analysis of comparative studies. The use of autogenous bone (AB) alone led to a significantly higher new bone formation if compared with bovine bone (BB) alone (P = 0.04), while no significant difference was found when the latter was compared with a mixture of AB and BB (P = 0.52). Grafts composed of BB showed significantly greater new bone formation as compared to hydroxyapatite (HA) (P < 0.001) while a mixture of tricalcium phosphate (TCP) and HA achieved better outcomes than BB (P < 0.001). Conclusions: Based on histomorphometric evaluation, AB should still be taken into consideration when the highest possible new bone formation is the primary aim in maxillary sinus surgery. When donor site morbidity is a concern, BB and a mixture of TCP and HA could be considered as predictable, showing promising results. More comparative histologic studies are needed to confirm such results.

Original languageEnglish
Pages (from-to)1106-1122
Number of pages17
JournalClinical Oral Implants Research
Volume27
Issue number9
DOIs
Publication statusPublished - Sep 1 2016

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Transverse Sinuses
Meta-Analysis
Bone and Bones
Osteogenesis
Durapatite
Maxillary Sinus
Biocompatible Materials
Biopsy
Residual Volume
Connective Tissue

Keywords

  • biomaterials
  • bone regeneration
  • guided tissue regeneration
  • sinus floor elevation

ASJC Scopus subject areas

  • Oral Surgery

Cite this

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title = "Histomorphometric outcomes after lateral sinus floor elevation procedure: a systematic review of the literature and meta-analysis",
abstract = "Objectives: The aim of the present systematic review of the literature was to evaluate biomaterials performances considering new bone formation estimated through histomorphometric analysis of bone biopsies from human subjects after maxillary sinus floor elevation. Materials and methods: An electronic and manual search was performed to retrieve articles showing histomorphometric data of bone biopsies performed after sinus floor elevation surgery. Recorded data were statistically analyzed evaluating percentage of new bone volume, residual biomaterial, and connective/soft tissues in the biopsies. A meta-analysis of comparative studies was also performed. Results: After article selection process, 84 articles were included in the quantitative synthesis and 16 of them in the meta-analysis of comparative studies. The use of autogenous bone (AB) alone led to a significantly higher new bone formation if compared with bovine bone (BB) alone (P = 0.04), while no significant difference was found when the latter was compared with a mixture of AB and BB (P = 0.52). Grafts composed of BB showed significantly greater new bone formation as compared to hydroxyapatite (HA) (P < 0.001) while a mixture of tricalcium phosphate (TCP) and HA achieved better outcomes than BB (P < 0.001). Conclusions: Based on histomorphometric evaluation, AB should still be taken into consideration when the highest possible new bone formation is the primary aim in maxillary sinus surgery. When donor site morbidity is a concern, BB and a mixture of TCP and HA could be considered as predictable, showing promising results. More comparative histologic studies are needed to confirm such results.",
keywords = "biomaterials, bone regeneration, guided tissue regeneration, sinus floor elevation",
author = "Stefano Corbella and Silvio Taschieri and Roberto Weinstein and {Del Fabbro}, Massimo",
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T2 - a systematic review of the literature and meta-analysis

AU - Corbella, Stefano

AU - Taschieri, Silvio

AU - Weinstein, Roberto

AU - Del Fabbro, Massimo

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N2 - Objectives: The aim of the present systematic review of the literature was to evaluate biomaterials performances considering new bone formation estimated through histomorphometric analysis of bone biopsies from human subjects after maxillary sinus floor elevation. Materials and methods: An electronic and manual search was performed to retrieve articles showing histomorphometric data of bone biopsies performed after sinus floor elevation surgery. Recorded data were statistically analyzed evaluating percentage of new bone volume, residual biomaterial, and connective/soft tissues in the biopsies. A meta-analysis of comparative studies was also performed. Results: After article selection process, 84 articles were included in the quantitative synthesis and 16 of them in the meta-analysis of comparative studies. The use of autogenous bone (AB) alone led to a significantly higher new bone formation if compared with bovine bone (BB) alone (P = 0.04), while no significant difference was found when the latter was compared with a mixture of AB and BB (P = 0.52). Grafts composed of BB showed significantly greater new bone formation as compared to hydroxyapatite (HA) (P < 0.001) while a mixture of tricalcium phosphate (TCP) and HA achieved better outcomes than BB (P < 0.001). Conclusions: Based on histomorphometric evaluation, AB should still be taken into consideration when the highest possible new bone formation is the primary aim in maxillary sinus surgery. When donor site morbidity is a concern, BB and a mixture of TCP and HA could be considered as predictable, showing promising results. More comparative histologic studies are needed to confirm such results.

AB - Objectives: The aim of the present systematic review of the literature was to evaluate biomaterials performances considering new bone formation estimated through histomorphometric analysis of bone biopsies from human subjects after maxillary sinus floor elevation. Materials and methods: An electronic and manual search was performed to retrieve articles showing histomorphometric data of bone biopsies performed after sinus floor elevation surgery. Recorded data were statistically analyzed evaluating percentage of new bone volume, residual biomaterial, and connective/soft tissues in the biopsies. A meta-analysis of comparative studies was also performed. Results: After article selection process, 84 articles were included in the quantitative synthesis and 16 of them in the meta-analysis of comparative studies. The use of autogenous bone (AB) alone led to a significantly higher new bone formation if compared with bovine bone (BB) alone (P = 0.04), while no significant difference was found when the latter was compared with a mixture of AB and BB (P = 0.52). Grafts composed of BB showed significantly greater new bone formation as compared to hydroxyapatite (HA) (P < 0.001) while a mixture of tricalcium phosphate (TCP) and HA achieved better outcomes than BB (P < 0.001). Conclusions: Based on histomorphometric evaluation, AB should still be taken into consideration when the highest possible new bone formation is the primary aim in maxillary sinus surgery. When donor site morbidity is a concern, BB and a mixture of TCP and HA could be considered as predictable, showing promising results. More comparative histologic studies are needed to confirm such results.

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