Histomorphometric, ultrastructural and microhardness evaluation of the osseointegration of a nanostructured titanium oxide coating by metal-organic chemical vapour deposition: An in vivo study

Gianluca Giavaresi, Luigi Ambrosio, Giovanni A. Battiston, Umberto Casellato, Rosalba Gerbasi, Milena Finia, Nicolò Nicoli Aldini, Lucia Martini, Lia Rimondini, Roberto Giardino

Research output: Contribution to journalArticle


Over the past decade the increase of elderly population has determined a rise in the incidence of bone fractures, and the improvement of the implant-bone interface remains an open problem. Metal-organic chemical vapour deposition (MOCVD) has recently been proposed as a technique to coat orthopaedic and dental prostheses with metal nanostructured oxide films either through the decomposition of oxygenated compounds (single-source precursors) or the reaction of oxygen-free metal compounds with oxygenating agents. The present study was performed to assess the in vivo biocompatibility of commercially pure Ti (control material: TI/MA) implants (∅ 2mm×5mm length) coated with nanostructured TiO2 films by MOCVD (Ti/MOCVD) and then inserted into rabbit femoral cortical (middhiaphysis) and cancellous (distal epiphysis) bone. Histomorphometric, ultrastructural and microhardness investigations were carried out. Four and 12 weeks after surgery, significant (p2 coating positively affects the osseointegration rate of commercially pure Ti implants and the bone mineralization at the bone-biomaterial interface in both cortical and cancellous bone.

Original languageEnglish
Pages (from-to)5583-5591
Number of pages9
Issue number25
Publication statusPublished - Nov 2004



  • Histomorphometry
  • Mechanical properties
  • Metal surface treatment
  • Osseointegration
  • Scanning electron microscopy (SEM)
  • Titanium oxide

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

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