Histone acetylation: a step in gene activation.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Cellular ageing appears to consist mainly in a loss of adaptability and a progressive decrease in the capacity of the cell to maintain homeostasis. Such age related phenomenon can be the result of stochastic or of programmed events, and may occur through changes in the base pairs or coding of the DNA, through increasing levels of error in transcription and finally through alterations at the translation step of proteins synthesis. The purpose of this chapter is to present histone acetylation as a key event in the control of chromatin structure and transcription.

Original languageEnglish
Pages (from-to)583-596
Number of pages14
JournalAdvances in Experimental Medicine and Biology
Volume231
Publication statusPublished - 1988

Fingerprint

Acetylation
Cell Aging
Protein Biosynthesis
Transcription
Base Pairing
Histones
Transcriptional Activation
Chromatin
Homeostasis
Genes
Chemical activation
DNA
Aging of materials
Proteins

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Histone acetylation : a step in gene activation. / Vidali, G.; Ferrari, N.; Pfeffer, U.

In: Advances in Experimental Medicine and Biology, Vol. 231, 1988, p. 583-596.

Research output: Contribution to journalArticle

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