Histone variants and lipid metabolism

Michela Borghesan, Gianluigi Mazzoccoli, Fareeba Sheedfar, Jude Oben, Valerio Pazienza, Manlio Vinciguerra

Research output: Contribution to journalArticlepeer-review


Within nucleosomes, canonical histones package the genome, but they can be opportunely replaced with histone variants. The incorporation of histone variants into the nucleosome is a chief cellular strategy to regulate transcription and cellular metabolism. In pathological terms, cellular steatosis is an abnormal accumulation of lipids, which reflects impairment in the turnover of triacylglycerols, affecting any organ but mainly the liver. The present review aims to summarize the experimental evidence for histone variant functions in lipid metabolism.

Original languageEnglish
Pages (from-to)1409-1413
Number of pages5
JournalBiochemical Society Transactions
Issue number5
Publication statusPublished - Oct 1 2014


  • Gene expression
  • Histone variant
  • Lipid metabolism
  • Nucleosome
  • Steatosis

ASJC Scopus subject areas

  • Biochemistry
  • Medicine(all)


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