Histopathological analysis of canine and feline cancer treated with electrochemotherapy

Alfonso Baldi; Feliciano Baldi; Pasquale Mellone; Alfredo D'Avino; Gennaro Citro; Enrico P. Spugnini

Histopathological analysis of canine and feline cancer treated with electrochemotherapy

Alfonso Baldi, Feliciano Baldi, Pasquale Mellone, Alfredo D'Avino, Gennaro Citro, Enrico P. Spugnini

Istituto Regina Elena

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Electrochemotherapy (ECT) is a novel anticancer therapy that is currently being evaluated in human and pet cancer patients. ECT associates the administration of an anti-tumor agent to the delivery of trains of appropriate waveforms. In this chapter we describe the histological features of more than 400 bioptic specimens of tumors coming from a cohort of 215 companion animals with spontaneous tumors enrolled in different phase II ECT trials, over a 10 years period. Patterns of response suggest a dependence on tumor matrix content as well as unmasking of deep antigens, triggering immune mediated tumor eradication. Further studies on this topic are warranted in companion animals as well as humans in order to better define the histopathological response of tumor tissues to ECT treatment.

Original language	English
Title of host publication	Electroporation in Laboratory and Clinical Investigations
Publisher	Nova Science Publishers, Inc.
Pages	265-271
Number of pages	7
ISBN (Print)	9781616683276
Publication status	Published - 2011

Keywords

Biphasic pulse
Cat
Dog
Electrochemotherapy

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Cite this

Histopathological analysis of canine and feline cancer treated with electrochemotherapy. / Baldi, Alfonso; Baldi, Feliciano; Mellone, Pasquale; D'Avino, Alfredo; Citro, Gennaro; Spugnini, Enrico P.

Electroporation in Laboratory and Clinical Investigations. Nova Science Publishers, Inc., 2011. p. 265-271.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

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T1 - Histopathological analysis of canine and feline cancer treated with electrochemotherapy

AU - Baldi, Alfonso

AU - Baldi, Feliciano

AU - Mellone, Pasquale

AU - D'Avino, Alfredo

AU - Citro, Gennaro

AU - Spugnini, Enrico P.

PY - 2011

Y1 - 2011

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AB - Electrochemotherapy (ECT) is a novel anticancer therapy that is currently being evaluated in human and pet cancer patients. ECT associates the administration of an anti-tumor agent to the delivery of trains of appropriate waveforms. In this chapter we describe the histological features of more than 400 bioptic specimens of tumors coming from a cohort of 215 companion animals with spontaneous tumors enrolled in different phase II ECT trials, over a 10 years period. Patterns of response suggest a dependence on tumor matrix content as well as unmasking of deep antigens, triggering immune mediated tumor eradication. Further studies on this topic are warranted in companion animals as well as humans in order to better define the histopathological response of tumor tissues to ECT treatment.

KW - Biphasic pulse

KW - Cat

KW - Dog

KW - Electrochemotherapy

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M3 - Chapter

AN - SCOPUS:84892080430

SN - 9781616683276

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BT - Electroporation in Laboratory and Clinical Investigations

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ER -

Histopathological analysis of canine and feline cancer treated with electrochemotherapy

Abstract

Keywords

ASJC Scopus subject areas

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