Histopathological analysis of canine and feline cancer treated with electrochemotherapy

Alfonso Baldi, Feliciano Baldi, Pasquale Mellone, Alfredo D'Avino, Gennaro Citro, Enrico P. Spugnini

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Electrochemotherapy (ECT) is a novel anticancer therapy that is currently being evaluated in human and pet cancer patients. ECT associates the administration of an anti-tumor agent to the delivery of trains of appropriate waveforms. In this chapter we describe the histological features of more than 400 bioptic specimens of tumors coming from a cohort of 215 companion animals with spontaneous tumors enrolled in different phase II ECT trials, over a 10 years period. Patterns of response suggest a dependence on tumor matrix content as well as unmasking of deep antigens, triggering immune mediated tumor eradication. Further studies on this topic are warranted in companion animals as well as humans in order to better define the histopathological response of tumor tissues to ECT treatment.

Original languageEnglish
Title of host publicationElectroporation in Laboratory and Clinical Investigations
PublisherNova Science Publishers, Inc.
Pages265-271
Number of pages7
ISBN (Print)9781616683276
Publication statusPublished - 2011

Keywords

  • Biphasic pulse
  • Cat
  • Dog
  • Electrochemotherapy

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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