Histopathological atlas of renal diseases: Light chain deposition disease

Franco Ferrario, Maria Pia Rastaldi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Monoclonal diseases of B-cell lineage, often referred to as plasma cell dyscrasias, are characterized by abnormal and uncontrolled proliferation of a single clone of B cells at different maturation stages, with a more or less marked differentiation to immunoglobulin (Ig)-secreting plasma cells. Thus B-cell proliferation is usually associated with the production and secretion in blood of a monoclonal Ig or a fragment thereof. An ominous consequence of secretion of monoclonal Ig products is their deposition in tissue. These proteinaceous deposits can take the form of casts (in myeloma cast nephropathy), cristals (in myeloma-associated Fanconi's syndrome), fibrils (in light-chain [LC] amyloidosis), or granular precipitates (in monoclonal Ig deposition disease [LCDD].

Original languageEnglish
Pages (from-to)499-502
Number of pages4
JournalJournal of Nephrology
Volume18
Issue number5
Publication statusPublished - Sep 2005

Fingerprint

Atlases
Immunoglobulins
B-Lymphocytes
Kidney
Light
Fanconi Syndrome
Antibody-Producing Cells
Paraproteinemias
Cell Lineage
Amyloidosis
Plasma Cells
Clone Cells
Cell Proliferation

Keywords

  • Electrondense granular deposits
  • Light-chains
  • Nodular glomerulosclerosis

ASJC Scopus subject areas

  • Nephrology

Cite this

Histopathological atlas of renal diseases : Light chain deposition disease. / Ferrario, Franco; Rastaldi, Maria Pia.

In: Journal of Nephrology, Vol. 18, No. 5, 09.2005, p. 499-502.

Research output: Contribution to journalArticle

@article{71a977a2577b4c7395dc4df319031c2a,
title = "Histopathological atlas of renal diseases: Light chain deposition disease",
abstract = "Monoclonal diseases of B-cell lineage, often referred to as plasma cell dyscrasias, are characterized by abnormal and uncontrolled proliferation of a single clone of B cells at different maturation stages, with a more or less marked differentiation to immunoglobulin (Ig)-secreting plasma cells. Thus B-cell proliferation is usually associated with the production and secretion in blood of a monoclonal Ig or a fragment thereof. An ominous consequence of secretion of monoclonal Ig products is their deposition in tissue. These proteinaceous deposits can take the form of casts (in myeloma cast nephropathy), cristals (in myeloma-associated Fanconi's syndrome), fibrils (in light-chain [LC] amyloidosis), or granular precipitates (in monoclonal Ig deposition disease [LCDD].",
keywords = "Electrondense granular deposits, Light-chains, Nodular glomerulosclerosis",
author = "Franco Ferrario and Rastaldi, {Maria Pia}",
year = "2005",
month = "9",
language = "English",
volume = "18",
pages = "499--502",
journal = "Journal of Nephrology",
issn = "1121-8428",
publisher = "Springer International Publishing",
number = "5",

}

TY - JOUR

T1 - Histopathological atlas of renal diseases

T2 - Light chain deposition disease

AU - Ferrario, Franco

AU - Rastaldi, Maria Pia

PY - 2005/9

Y1 - 2005/9

N2 - Monoclonal diseases of B-cell lineage, often referred to as plasma cell dyscrasias, are characterized by abnormal and uncontrolled proliferation of a single clone of B cells at different maturation stages, with a more or less marked differentiation to immunoglobulin (Ig)-secreting plasma cells. Thus B-cell proliferation is usually associated with the production and secretion in blood of a monoclonal Ig or a fragment thereof. An ominous consequence of secretion of monoclonal Ig products is their deposition in tissue. These proteinaceous deposits can take the form of casts (in myeloma cast nephropathy), cristals (in myeloma-associated Fanconi's syndrome), fibrils (in light-chain [LC] amyloidosis), or granular precipitates (in monoclonal Ig deposition disease [LCDD].

AB - Monoclonal diseases of B-cell lineage, often referred to as plasma cell dyscrasias, are characterized by abnormal and uncontrolled proliferation of a single clone of B cells at different maturation stages, with a more or less marked differentiation to immunoglobulin (Ig)-secreting plasma cells. Thus B-cell proliferation is usually associated with the production and secretion in blood of a monoclonal Ig or a fragment thereof. An ominous consequence of secretion of monoclonal Ig products is their deposition in tissue. These proteinaceous deposits can take the form of casts (in myeloma cast nephropathy), cristals (in myeloma-associated Fanconi's syndrome), fibrils (in light-chain [LC] amyloidosis), or granular precipitates (in monoclonal Ig deposition disease [LCDD].

KW - Electrondense granular deposits

KW - Light-chains

KW - Nodular glomerulosclerosis

UR - http://www.scopus.com/inward/record.url?scp=29244468265&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=29244468265&partnerID=8YFLogxK

M3 - Article

C2 - 16299674

AN - SCOPUS:29244468265

VL - 18

SP - 499

EP - 502

JO - Journal of Nephrology

JF - Journal of Nephrology

SN - 1121-8428

IS - 5

ER -