Histopathological atlas of renal diseases: Minimal change disease and focal glomerulosclerosis

Franco Ferrario, Maria Pia Rastaldi

Research output: Contribution to journalArticle

Abstract

Minimal Change disease and focal segmental glomerulosclerosis are both clinically characterized by presence of Nephrotic Syndrome. The term Minimal Change disease describes a pathology appearance on light microscopy in which there are no definitive changes from normal glomeruli, although the degree of change that is considered significant remains the subject of some controversy. The focal segmental glomerulosclerosis is morphologically characterized by a segmental solidification of the glomerular tuft, due to collapse of the capillary wall, affecting only some glomeruli (focal). It remains unresolved whether Minimal Change disease and focal segmental glomerulosclerosis are different diseases or whether they represent a spectrum of presentation of the same disease process.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalJournal of Nephrology
Volume18
Issue number1
Publication statusPublished - Jan 2005

Keywords

  • Epithelial visceral cells
  • Foot processes effacement
  • Mesangial hypertrophy
  • Segmental sclerosis

ASJC Scopus subject areas

  • Nephrology

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