Histopathological characteristics of subsequent melanomas in patients with multiple primary melanomas

A. Vecchiato, S. Pasquali, C. Menin, M. C. Montesco, M. Alaibac, S. Mocellin, L. G. Campana, D. Nitti, C. R. Rossi

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Abstract

Background Multiple primary melanomas (MPM) occur in up to 20% of melanoma patients, and subsequent tumours seem to have a favourable histopathological pattern. Objective A prospectively collected cohort of 194 patients with MPM was retrospectively reviewed to investigate clinical and histopathological features of first and subsequent melanomas. Methods Patients with MPM who were diagnosed at our Department (1985-2011) and who attended at least a follow-up control yearly were identified. Results The number of nevi was 50 in 8.7%, 41% and 50.3% of patients respectively. Histopathological dysplastic nevi have been diagnosed in 105 patients. During a median follow-up of 58 months, 159 (81.9%), 24 (12.3%), 7 (3.6%) and 4 (2%) patients developed 2, 3, 4 and ≥5 melanomas, respectively. The median time to second primary melanoma was 45 months. The second primary melanoma was diagnosed within 1-year and after 5-year from the first melanoma in 36.6% and 17.3% of patients respectively. First and second primary melanomas were in situ in 41 (21%) and 104 (54%) patients respectively (P <0.001). Among patients with ≥2 invasive melanomas (N = 80), median tumour thickness and ulceration of first and second primaries were 0.91 and 0.44 mm (P <0.001), and 32% and 7.7% (P = 0.001) respectively. Conclusions Subsequent melanomas occurred within 1-year from the appearance of the first melanoma in 36% of patients with MPM, while a late melanoma diagnosis was detected in 17% of cases. Second primary melanoma had favourable histopathological features. Our findings support long-term skin surveillance to detect subsequent melanomas at an early stage.

Original languageEnglish
Pages (from-to)58-64
Number of pages7
JournalJournal of the European Academy of Dermatology and Venereology
Volume28
Issue number1
DOIs
Publication statusPublished - Jan 2014

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Melanoma
Dysplastic Nevus Syndrome
Nevus
Delayed Diagnosis
Neoplasms

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

Cite this

@article{7c1890a8c0144ae2ac34e2799a2d7cc1,
title = "Histopathological characteristics of subsequent melanomas in patients with multiple primary melanomas",
abstract = "Background Multiple primary melanomas (MPM) occur in up to 20{\%} of melanoma patients, and subsequent tumours seem to have a favourable histopathological pattern. Objective A prospectively collected cohort of 194 patients with MPM was retrospectively reviewed to investigate clinical and histopathological features of first and subsequent melanomas. Methods Patients with MPM who were diagnosed at our Department (1985-2011) and who attended at least a follow-up control yearly were identified. Results The number of nevi was 50 in 8.7{\%}, 41{\%} and 50.3{\%} of patients respectively. Histopathological dysplastic nevi have been diagnosed in 105 patients. During a median follow-up of 58 months, 159 (81.9{\%}), 24 (12.3{\%}), 7 (3.6{\%}) and 4 (2{\%}) patients developed 2, 3, 4 and ≥5 melanomas, respectively. The median time to second primary melanoma was 45 months. The second primary melanoma was diagnosed within 1-year and after 5-year from the first melanoma in 36.6{\%} and 17.3{\%} of patients respectively. First and second primary melanomas were in situ in 41 (21{\%}) and 104 (54{\%}) patients respectively (P <0.001). Among patients with ≥2 invasive melanomas (N = 80), median tumour thickness and ulceration of first and second primaries were 0.91 and 0.44 mm (P <0.001), and 32{\%} and 7.7{\%} (P = 0.001) respectively. Conclusions Subsequent melanomas occurred within 1-year from the appearance of the first melanoma in 36{\%} of patients with MPM, while a late melanoma diagnosis was detected in 17{\%} of cases. Second primary melanoma had favourable histopathological features. Our findings support long-term skin surveillance to detect subsequent melanomas at an early stage.",
author = "A. Vecchiato and S. Pasquali and C. Menin and Montesco, {M. C.} and M. Alaibac and S. Mocellin and Campana, {L. G.} and D. Nitti and Rossi, {C. R.}",
year = "2014",
month = "1",
doi = "10.1111/jdv.12055",
language = "English",
volume = "28",
pages = "58--64",
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TY - JOUR

T1 - Histopathological characteristics of subsequent melanomas in patients with multiple primary melanomas

AU - Vecchiato, A.

AU - Pasquali, S.

AU - Menin, C.

AU - Montesco, M. C.

AU - Alaibac, M.

AU - Mocellin, S.

AU - Campana, L. G.

AU - Nitti, D.

AU - Rossi, C. R.

PY - 2014/1

Y1 - 2014/1

N2 - Background Multiple primary melanomas (MPM) occur in up to 20% of melanoma patients, and subsequent tumours seem to have a favourable histopathological pattern. Objective A prospectively collected cohort of 194 patients with MPM was retrospectively reviewed to investigate clinical and histopathological features of first and subsequent melanomas. Methods Patients with MPM who were diagnosed at our Department (1985-2011) and who attended at least a follow-up control yearly were identified. Results The number of nevi was 50 in 8.7%, 41% and 50.3% of patients respectively. Histopathological dysplastic nevi have been diagnosed in 105 patients. During a median follow-up of 58 months, 159 (81.9%), 24 (12.3%), 7 (3.6%) and 4 (2%) patients developed 2, 3, 4 and ≥5 melanomas, respectively. The median time to second primary melanoma was 45 months. The second primary melanoma was diagnosed within 1-year and after 5-year from the first melanoma in 36.6% and 17.3% of patients respectively. First and second primary melanomas were in situ in 41 (21%) and 104 (54%) patients respectively (P <0.001). Among patients with ≥2 invasive melanomas (N = 80), median tumour thickness and ulceration of first and second primaries were 0.91 and 0.44 mm (P <0.001), and 32% and 7.7% (P = 0.001) respectively. Conclusions Subsequent melanomas occurred within 1-year from the appearance of the first melanoma in 36% of patients with MPM, while a late melanoma diagnosis was detected in 17% of cases. Second primary melanoma had favourable histopathological features. Our findings support long-term skin surveillance to detect subsequent melanomas at an early stage.

AB - Background Multiple primary melanomas (MPM) occur in up to 20% of melanoma patients, and subsequent tumours seem to have a favourable histopathological pattern. Objective A prospectively collected cohort of 194 patients with MPM was retrospectively reviewed to investigate clinical and histopathological features of first and subsequent melanomas. Methods Patients with MPM who were diagnosed at our Department (1985-2011) and who attended at least a follow-up control yearly were identified. Results The number of nevi was 50 in 8.7%, 41% and 50.3% of patients respectively. Histopathological dysplastic nevi have been diagnosed in 105 patients. During a median follow-up of 58 months, 159 (81.9%), 24 (12.3%), 7 (3.6%) and 4 (2%) patients developed 2, 3, 4 and ≥5 melanomas, respectively. The median time to second primary melanoma was 45 months. The second primary melanoma was diagnosed within 1-year and after 5-year from the first melanoma in 36.6% and 17.3% of patients respectively. First and second primary melanomas were in situ in 41 (21%) and 104 (54%) patients respectively (P <0.001). Among patients with ≥2 invasive melanomas (N = 80), median tumour thickness and ulceration of first and second primaries were 0.91 and 0.44 mm (P <0.001), and 32% and 7.7% (P = 0.001) respectively. Conclusions Subsequent melanomas occurred within 1-year from the appearance of the first melanoma in 36% of patients with MPM, while a late melanoma diagnosis was detected in 17% of cases. Second primary melanoma had favourable histopathological features. Our findings support long-term skin surveillance to detect subsequent melanomas at an early stage.

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U2 - 10.1111/jdv.12055

DO - 10.1111/jdv.12055

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C2 - 23216522

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VL - 28

SP - 58

EP - 64

JO - Journal of the European Academy of Dermatology and Venereology

JF - Journal of the European Academy of Dermatology and Venereology

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