Histopathological classification of nonantral gastric endocrine growths in man

Enrico Solcia, C. Bordi, W. Creutzfeldt, Y. Dayal, A. D. Dayan, S. Falkmer, L. Grimeliust, N. Havu

Research output: Contribution to journalArticlepeer-review


Recently, the gastric endocrine system has been recognized as the origin of benign and malignant tumors in pernicious anemia. It has also been found that the gastric endocrine cells respond to permanent elevation of serum gastrin levels induced by changes in acid secretion in response to surgical procedures, drug therapy and age. Therefore, a definition of nonantral gastric endocrine hyperplasia (simple or diffuse, linear or chain-forming, micronodular, adenomatoid), dysplasia (enlarging or fusing micronodules, microinvasion, nodular growth) and neoplasia (intramucosal carcinoid, invasive carcinoid) is presented. The individual entities are illustrated, together with the literature discussed and the techniques for their identification presented.

Original languageEnglish
Pages (from-to)185-200
Number of pages16
Issue number4
Publication statusPublished - 1988


  • Argyrophilic cells
  • Carcinoidosis
  • ECL cell tumors
  • ECL cells
  • Gastric carcinoids
  • Gastric endocrine cells

ASJC Scopus subject areas

  • Gastroenterology


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