Histopathological differences of myotonic dystrophy type 1 (DM1) and PROMM/DM2

A. Vihola, G. Bassez, G. Meola, S. Zhang, H. Haapasalo, A. Paetau, E. Mancinelli, A. Rouche, J. Y. Hogrel, P. Laforêt, T. Maisonobe, J. F. Pellissier, R. Krahe, B. Eymard, Bjarne Udd

Research output: Contribution to journalArticle

Abstract

Muscle biopsy findings in DM2 have been reported to be similar to those in DM1. The authors used myosin heavy chain immunohistochemistry and enzyme histochemistry for fiber type differentiation on muscle biopsies. Their results show that DM2 patients display a subpopulation of type 2 nuclear clump and other very small fibers and, hence, preferential type 2 fiber atrophy in contrast to type 1 fiber atrophy in DM1 patients.

Original languageEnglish
Pages (from-to)1854-1857
Number of pages4
JournalNeurology
Volume60
Issue number11
Publication statusPublished - Jun 10 2003

ASJC Scopus subject areas

  • Neuroscience(all)

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    Vihola, A., Bassez, G., Meola, G., Zhang, S., Haapasalo, H., Paetau, A., Mancinelli, E., Rouche, A., Hogrel, J. Y., Laforêt, P., Maisonobe, T., Pellissier, J. F., Krahe, R., Eymard, B., & Udd, B. (2003). Histopathological differences of myotonic dystrophy type 1 (DM1) and PROMM/DM2. Neurology, 60(11), 1854-1857.