Historical recombinant sites in extended HLA haplotypes

S. D'Alfonso, E. Bolognesi, G. Mazzola, A. Dall'Omo, P. Momigliano Richiardi

Research output: Contribution to journalArticle

Abstract

Each ancestral or extended HLA haplotype contains a unique combination of alleles among which some may be entirely specific for that haplotype (haplospecific alleles). In the course of evolution many recombination events occurred which disrupted the original haplotypic combination. We analysed the sites of historical recombinations in four extended HLA haplotypes (B8-DR3; B18-DR3; B50-DR7 and B57-DR7) in 60 random Italian individuals selected through the presence of haplospecific alleles. In general the distribution of recombinations in each interval was similar for the four extended haplotypes and no haplospecific recombination ″hot spot″ could be detected. However some differences between the four haplotypes can be pointed out: a) only 48% fragmented B8-DR3 were found in contrast to 83% B18-DR3, 89% B50-DR7 and 88% B57-DR7; b) in the B8-DR3 haplotype recombinations fall preferentially in the B/TNF interval. In fact among 22 historical recombination events, 50% were mapped in this region; c) conversely, no recombination event was detected in the B/TNF interval among the 19 disrupted B18-DR3 haplotypes thus evidencing the presence of a putative recombination ″cold spot″.

Original languageEnglish
Pages (from-to)8-13
Number of pages6
JournalJournal of Biological Regulators and Homeostatic Agents
Volume13
Issue number1
Publication statusPublished - 1999

Keywords

  • Extended HLA haplotypes
  • Haplospecific markers
  • Recombination sites

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Endocrinology
  • Physiology
  • Immunology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Physiology (medical)

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    D'Alfonso, S., Bolognesi, E., Mazzola, G., Dall'Omo, A., & Momigliano Richiardi, P. (1999). Historical recombinant sites in extended HLA haplotypes. Journal of Biological Regulators and Homeostatic Agents, 13(1), 8-13.