TY - JOUR
T1 - History of cancer in first degree relatives of Barrett's esophagus patients
T2 - A case-control study
AU - De Ceglie, Antonella
AU - Filiberti, Rosa
AU - Blanchi, Sabrina
AU - Fontana, Vincenzo
AU - Fisher, Deborah A.
AU - Grossi, Enzo
AU - Lacchin, Teresa
AU - De Matthaeis, Marina
AU - Ignomirelli, Orazio
AU - Cappiello, Roberta
AU - Casa, Domenico Della
AU - Foti, Monica
AU - Laterza, Francesco
AU - Rosati, Riccardo
AU - Annese, Vito
AU - Iaquinto, Gaetano
AU - Conio, Massimo
PY - 1800
Y1 - 1800
N2 - Background and objective: Familial clusters of Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) have been reported. This study evaluates the history of cancer in BE patients families. Methods: In two years, patients with BE (272), esophagitis (456) and controls (517) were recruited in 12 Italian Endoscopy Units. Cancer family history in first-degree (FD) relatives was determined by a questionnaire. Results: Approximately 53% of BE, 51% of esophagitis, and 48% of controls had at least one relative affected by any type of malignancy. Probands with at least one esophageal or gastric (E/G) cancer-affected relative showed a BE risk which was at least eighty-five percent higher than that of probands without affected relatives. The relative risk of BE was 4.18, 95% CL = 0.76-23.04 if a FD relative had early (mean age ≤50 years) onset E/G cancer compared to late onset E/G cancer. Conclusion: In this sample there was no evidence that a family history of cancer was associated with the diagnosis of BE. An intriguing result was the association between the occurrence of E/G cancers at earlier ages (<50 years) among BE relatives with respect the control group. This could suggest a genetic contribution in onset of these tumors, but the sample was too small to demonstrate a significant association. Further exploration of family history of E/G cancer and a diagnosis of BE in larger samples is warranted.
AB - Background and objective: Familial clusters of Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) have been reported. This study evaluates the history of cancer in BE patients families. Methods: In two years, patients with BE (272), esophagitis (456) and controls (517) were recruited in 12 Italian Endoscopy Units. Cancer family history in first-degree (FD) relatives was determined by a questionnaire. Results: Approximately 53% of BE, 51% of esophagitis, and 48% of controls had at least one relative affected by any type of malignancy. Probands with at least one esophageal or gastric (E/G) cancer-affected relative showed a BE risk which was at least eighty-five percent higher than that of probands without affected relatives. The relative risk of BE was 4.18, 95% CL = 0.76-23.04 if a FD relative had early (mean age ≤50 years) onset E/G cancer compared to late onset E/G cancer. Conclusion: In this sample there was no evidence that a family history of cancer was associated with the diagnosis of BE. An intriguing result was the association between the occurrence of E/G cancers at earlier ages (<50 years) among BE relatives with respect the control group. This could suggest a genetic contribution in onset of these tumors, but the sample was too small to demonstrate a significant association. Further exploration of family history of E/G cancer and a diagnosis of BE in larger samples is warranted.
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U2 - 10.1016/j.clinre.2011.07.015
DO - 10.1016/j.clinre.2011.07.015
M3 - Article
AN - SCOPUS:80052582899
JO - Clinics and Research in Hepatology and Gastroenterology
JF - Clinics and Research in Hepatology and Gastroenterology
SN - 2210-7401
ER -