History of cancer in first degree relatives of Barrett's esophagus patients: A case-control study

Antonella De Ceglie, Rosa Filiberti, Sabrina Blanchi, Vincenzo Fontana, Deborah A. Fisher, Enzo Grossi, Teresa Lacchin, Marina De Matthaeis, Orazio Ignomirelli, Roberta Cappiello, Domenico Della Casa, Monica Foti, Francesco Laterza, Riccardo Rosati, Vito Annese, Gaetano Iaquinto, Massimo Conio

Research output: Contribution to journalArticle

Abstract

Background and objective: Familial clusters of Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) have been reported. This study evaluates the history of cancer in BE patients families. Methods: In two years, patients with BE (272), esophagitis (456) and controls (517) were recruited in 12 Italian Endoscopy Units. Cancer family history in first-degree (FD) relatives was determined by a questionnaire. Results: Approximately 53% of BE, 51% of esophagitis, and 48% of controls had at least one relative affected by any type of malignancy. Probands with at least one esophageal or gastric (E/G) cancer-affected relative showed a BE risk which was at least eighty-five percent higher than that of probands without affected relatives. The relative risk of BE was 4.18, 95% CL = 0.76-23.04 if a FD relative had early (mean age ≤50 years) onset E/G cancer compared to late onset E/G cancer. Conclusion: In this sample there was no evidence that a family history of cancer was associated with the diagnosis of BE. An intriguing result was the association between the occurrence of E/G cancers at earlier ages (<50 years) among BE relatives with respect the control group. This could suggest a genetic contribution in onset of these tumors, but the sample was too small to demonstrate a significant association. Further exploration of family history of E/G cancer and a diagnosis of BE in larger samples is warranted.

Original languageEnglish
JournalClinics and Research in Hepatology and Gastroenterology
DOIs
Publication statusAccepted/In press - 1800

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Barrett Esophagus
Case-Control Studies
Esophageal Neoplasms
Stomach Neoplasms
Neoplasms
Esophagitis
Endoscopy
Adenocarcinoma
History
Control Groups

ASJC Scopus subject areas

  • Gastroenterology

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History of cancer in first degree relatives of Barrett's esophagus patients : A case-control study. / De Ceglie, Antonella; Filiberti, Rosa; Blanchi, Sabrina; Fontana, Vincenzo; Fisher, Deborah A.; Grossi, Enzo; Lacchin, Teresa; De Matthaeis, Marina; Ignomirelli, Orazio; Cappiello, Roberta; Casa, Domenico Della; Foti, Monica; Laterza, Francesco; Rosati, Riccardo; Annese, Vito; Iaquinto, Gaetano; Conio, Massimo.

In: Clinics and Research in Hepatology and Gastroenterology, 1800.

Research output: Contribution to journalArticle

De Ceglie, A, Filiberti, R, Blanchi, S, Fontana, V, Fisher, DA, Grossi, E, Lacchin, T, De Matthaeis, M, Ignomirelli, O, Cappiello, R, Casa, DD, Foti, M, Laterza, F, Rosati, R, Annese, V, Iaquinto, G & Conio, M 1800, 'History of cancer in first degree relatives of Barrett's esophagus patients: A case-control study', Clinics and Research in Hepatology and Gastroenterology. https://doi.org/10.1016/j.clinre.2011.07.015
De Ceglie, Antonella ; Filiberti, Rosa ; Blanchi, Sabrina ; Fontana, Vincenzo ; Fisher, Deborah A. ; Grossi, Enzo ; Lacchin, Teresa ; De Matthaeis, Marina ; Ignomirelli, Orazio ; Cappiello, Roberta ; Casa, Domenico Della ; Foti, Monica ; Laterza, Francesco ; Rosati, Riccardo ; Annese, Vito ; Iaquinto, Gaetano ; Conio, Massimo. / History of cancer in first degree relatives of Barrett's esophagus patients : A case-control study. In: Clinics and Research in Hepatology and Gastroenterology. 1800.
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T1 - History of cancer in first degree relatives of Barrett's esophagus patients

T2 - A case-control study

AU - De Ceglie, Antonella

AU - Filiberti, Rosa

AU - Blanchi, Sabrina

AU - Fontana, Vincenzo

AU - Fisher, Deborah A.

AU - Grossi, Enzo

AU - Lacchin, Teresa

AU - De Matthaeis, Marina

AU - Ignomirelli, Orazio

AU - Cappiello, Roberta

AU - Casa, Domenico Della

AU - Foti, Monica

AU - Laterza, Francesco

AU - Rosati, Riccardo

AU - Annese, Vito

AU - Iaquinto, Gaetano

AU - Conio, Massimo

PY - 1800

Y1 - 1800

N2 - Background and objective: Familial clusters of Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) have been reported. This study evaluates the history of cancer in BE patients families. Methods: In two years, patients with BE (272), esophagitis (456) and controls (517) were recruited in 12 Italian Endoscopy Units. Cancer family history in first-degree (FD) relatives was determined by a questionnaire. Results: Approximately 53% of BE, 51% of esophagitis, and 48% of controls had at least one relative affected by any type of malignancy. Probands with at least one esophageal or gastric (E/G) cancer-affected relative showed a BE risk which was at least eighty-five percent higher than that of probands without affected relatives. The relative risk of BE was 4.18, 95% CL = 0.76-23.04 if a FD relative had early (mean age ≤50 years) onset E/G cancer compared to late onset E/G cancer. Conclusion: In this sample there was no evidence that a family history of cancer was associated with the diagnosis of BE. An intriguing result was the association between the occurrence of E/G cancers at earlier ages (<50 years) among BE relatives with respect the control group. This could suggest a genetic contribution in onset of these tumors, but the sample was too small to demonstrate a significant association. Further exploration of family history of E/G cancer and a diagnosis of BE in larger samples is warranted.

AB - Background and objective: Familial clusters of Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) have been reported. This study evaluates the history of cancer in BE patients families. Methods: In two years, patients with BE (272), esophagitis (456) and controls (517) were recruited in 12 Italian Endoscopy Units. Cancer family history in first-degree (FD) relatives was determined by a questionnaire. Results: Approximately 53% of BE, 51% of esophagitis, and 48% of controls had at least one relative affected by any type of malignancy. Probands with at least one esophageal or gastric (E/G) cancer-affected relative showed a BE risk which was at least eighty-five percent higher than that of probands without affected relatives. The relative risk of BE was 4.18, 95% CL = 0.76-23.04 if a FD relative had early (mean age ≤50 years) onset E/G cancer compared to late onset E/G cancer. Conclusion: In this sample there was no evidence that a family history of cancer was associated with the diagnosis of BE. An intriguing result was the association between the occurrence of E/G cancers at earlier ages (<50 years) among BE relatives with respect the control group. This could suggest a genetic contribution in onset of these tumors, but the sample was too small to demonstrate a significant association. Further exploration of family history of E/G cancer and a diagnosis of BE in larger samples is warranted.

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