History of fat grafting: From ram fat to stem cells

Riccardo F. Mazzola, Isabella C. Mazzola

Research output: Contribution to journalArticlepeer-review


Fat injection empirically started 100 year ago to correct contour deformities mainly on the face and breast. The German surgeon Eugene Hollaender (1867-1932) proposed a cocktail of human and ram fat, to avoid reabsorption. Nowadays, fat injection has evolved, and it ranks among the most popular procedures, for it provides the physician with a range of aesthetic and reconstructive clinical applications with regenerative effects on the surrounding tissues. New research from all over the world has demonstrated the role of adipose-derived stem cells, present in the adipose tissue, in the repair of damaged or missing tissues.

Original languageEnglish
Pages (from-to)147-153
Number of pages7
JournalClinics in Plastic Surgery
Issue number2
Publication statusPublished - Apr 1 2015


  • Adipose derived stem cells
  • Fat injection
  • History of fat grafting
  • History of surgery
  • Regenerative medicine

ASJC Scopus subject areas

  • Surgery
  • Medicine(all)


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