History of thyroid diseases and subsequent thyroid cancer risk

B. D'Avanzo, C. La Vecchia, S. Franceschi, E. Negri, R. Talamini

Research output: Contribution to journalArticlepeer-review


A history of benign thyroid diseases has been associated with the risk of thyroid cancer. We have analyzed this issue using data from a case-control study conducted in northern Italy between 1986 and 1992 on 399 incident, histologically confirmed thyroid cancer cases and 617 controls admitted to the hospital for acute, nonneoplastic, non-hormone-related diseases. The overall multivariate relative risk (RR) estimates were 2.8 [95% confidence interval (CI), 0.6-12.4] for previous episodes of thyroiditis, 27.1 (95% CI, 6.5-111.9) for adenoma, 8.2 (95% CI, 3.5-19.1) for goiter, 3.8 (95% CI, 1.4- 10.9) for hyperthyroidism, and 1.5 (95% CI, 0.4-5.1) for hypothyroidism when all histotypes were analyzed. The RR for any thyroid disease was 7.7 (95% CI, 4.6-12.8). A family history of thyroid disease was significantly related to thyroid cancer with an RR of 1.6. The RR for having resided in endemic goiter areas was 1.3 for

Original languageEnglish
Pages (from-to)193-199
Number of pages7
JournalCancer Epidemiology Biomarkers and Prevention
Issue number3
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Epidemiology
  • Oncology


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