History of weight and obesity through life and risk of benign prostatic hyperplasia

A. Zucchetto, A. Tavani, L. Dal Maso, S. Gallus, E. Negri, R. Talamini, S. Franceschi, M. Montella, C. La Vecchia

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

OBJECTIVE: The relation of anthropometric measures, diabetes, hypertension and hyperlipidemia with benign prostatic hyperplasia (BPH) risk was investigated. DESIGN: Hospital-based case-control study. SUBJECTS: Cases were 1369 men with histologically confirmed BPH, and controls were 1451 men below 75 y, admitted to hospital for acute non-neoplastic diseases. MEASUREMENTS: Using a structured questionnaire, trained interviewers collected information on self-reported height and weight, and measured waist and hip circumference of patients. The odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional multiple logistic regression models. RESULTS: Compared to the corresponding lowest quartile, the OR for the highest one were 0.76 (95% CI 0.59-0.98) for body weight, 0.71 (95% CI 0.54-0.94) for waist-to-hip ratio and 0.87 (95% CI 0.70-1.09) for body mass index (BMI, kg/m2). Compared to a lowest lifelong BMI 2, the OR was 1.56 (95% CI 1.25-1.95) for a lowest lifelong BMI ≥23.7 kg/m2. The OR was 0.74 (95% CI 0.60-0.93) for a lifelong increase of BMI ≥6.1 kg/m2, compared to 2. No association emerged for history of diabetes, hypertension and hyperlipidemia. CONCLUSIONS: Overweight was modestly, inversely related to BPH. The hypothesis of reduced testosterone levels in obese individuals may explain the different BPH risk and need to be tested.

Original languageEnglish
Pages (from-to)798-803
Number of pages6
JournalInternational Journal of Obesity
Volume29
Issue number7
DOIs
Publication statusPublished - Jul 2005

Fingerprint

Prostatic Hyperplasia
hyperplasia
confidence interval
obesity
Obesity
Confidence Intervals
Weights and Measures
odds ratio
Odds Ratio
hyperlipidemia
Hyperlipidemias
hypertension
diabetes
Logistic Models
Hypertension
waist-to-hip ratio
Waist-Hip Ratio
waist
Waist Circumference
case-control studies

Keywords

  • Anthropometric measures
  • Benign prostatic hyperplasia
  • Case-control studies
  • Diabetes
  • Hyperlipidemia
  • Hypertension

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

History of weight and obesity through life and risk of benign prostatic hyperplasia. / Zucchetto, A.; Tavani, A.; Dal Maso, L.; Gallus, S.; Negri, E.; Talamini, R.; Franceschi, S.; Montella, M.; La Vecchia, C.

In: International Journal of Obesity, Vol. 29, No. 7, 07.2005, p. 798-803.

Research output: Contribution to journalArticle

Zucchetto, A. ; Tavani, A. ; Dal Maso, L. ; Gallus, S. ; Negri, E. ; Talamini, R. ; Franceschi, S. ; Montella, M. ; La Vecchia, C. / History of weight and obesity through life and risk of benign prostatic hyperplasia. In: International Journal of Obesity. 2005 ; Vol. 29, No. 7. pp. 798-803.
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AU - Tavani, A.

AU - Dal Maso, L.

AU - Gallus, S.

AU - Negri, E.

AU - Talamini, R.

AU - Franceschi, S.

AU - Montella, M.

AU - La Vecchia, C.

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AB - OBJECTIVE: The relation of anthropometric measures, diabetes, hypertension and hyperlipidemia with benign prostatic hyperplasia (BPH) risk was investigated. DESIGN: Hospital-based case-control study. SUBJECTS: Cases were 1369 men with histologically confirmed BPH, and controls were 1451 men below 75 y, admitted to hospital for acute non-neoplastic diseases. MEASUREMENTS: Using a structured questionnaire, trained interviewers collected information on self-reported height and weight, and measured waist and hip circumference of patients. The odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional multiple logistic regression models. RESULTS: Compared to the corresponding lowest quartile, the OR for the highest one were 0.76 (95% CI 0.59-0.98) for body weight, 0.71 (95% CI 0.54-0.94) for waist-to-hip ratio and 0.87 (95% CI 0.70-1.09) for body mass index (BMI, kg/m2). Compared to a lowest lifelong BMI 2, the OR was 1.56 (95% CI 1.25-1.95) for a lowest lifelong BMI ≥23.7 kg/m2. The OR was 0.74 (95% CI 0.60-0.93) for a lifelong increase of BMI ≥6.1 kg/m2, compared to 2. No association emerged for history of diabetes, hypertension and hyperlipidemia. CONCLUSIONS: Overweight was modestly, inversely related to BPH. The hypothesis of reduced testosterone levels in obese individuals may explain the different BPH risk and need to be tested.

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