Hiv-1 and hiv-2 seroprevalence rates in mother-child pairs living in the gambia (West africa)

Annarosa Del Mistro, Jacques Chotard, Andrew J. Hall, Hilton Whittle, Anita De Rossi, Luigi Chieco-Bianchi

Research output: Contribution to journalArticlepeer-review


Summary: A seroepidemiological study was conducted, during 1988 and 1989, of mother-child pairs living in The Gambia (West Africa) in order to determine the distribution of the human immunodeficiency viruses type 1 (HIV-1) and type 2 (HIV-2). Specimens were obtained from 931 children (age range, 14–17 months) and 923 mothers (age range, 14–47 years) using village-based cluster samples; the children are participating in The Gambia Hepatitis Intervention Study (GHIS), a large-scale HBV vaccination program. Large numbers of indeterminate Western blot patterns were observed among the mothers, mainly for HIV-1 antibodies; HIV-1 infected subjects were not found, whereas an HIV-2 seroprevalence rate of 0.75% was observed. The children born to the seven HIV-2 positive women were seronegative for HIV-2 antibodies, and none of the children showed HIV-2 or HIV-1 seropostitivity.

Original languageEnglish
Pages (from-to)19-24
Number of pages6
JournalJournal of Acquired Immune Deficiency Syndromes
Issue number1
Publication statusPublished - 1992


  • HIV-1 and HIV-2 seroprevalence
  • The Gambia
  • Vertical transmission

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)
  • Virology
  • Immunology and Allergy


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