HIV-1 and parasitic infections in rural Tanzania

C. Atzori, A. Bruno, G. Chichino, C. Cevini, A. M. Bernuzzi, S. Gatti, G. Comolli, M. Scaglia

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A sample of 300 sexually-active adults was selected at random from patients, from the rural area of Malenga Makali, Tanzania, who were attending a dispensary because they had diarrhoea of at least 2 weeks' duration. The potential associations between the patient's health (in terms of the World Health Organization's clinical definition of AIDS), HIV-1 seroprevalence and malaria and other parasitic infections were then investigated. Although, HIV-1 seroprevalence was 20.6% overall, the level of seroprevalence was directly correlated with the distance between the patients' home villages and the nearest main road. Strict application of the clinical definition of AIDS gave 98.7% specificity, 46% sensitivity and a predictive value of 90.6% when validated by HIV-1 seropositivity. Although malaria infection was more common in HIV-1 seropositives than in the seronegatives, the intensity of the Plasmodium falciparum infections, intestinal amoebiasis and giardiasis did not appear to be correlated with HIV-1 infection. In contrast, intestinal infections with Cryptosporidium parcum and Isaspora belli were virtually restricted to HIV-1 seropositive individuals who had had diarrhoea for a relatively long time.

Original languageEnglish
Pages (from-to)585-593
Number of pages9
JournalAnnals of Tropical Medicine and Parasitology
Issue number6
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Immunology
  • Parasitology
  • Infectious Diseases


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