HIV-1-derived lentiviral vectors directly activate plasmacytoid dendritic cells, which in turn induce the maturation of myeloid dendritic cells

Maura Rossetti, Silvia Gregori, Ehud Hauben, Brian D. Brown, Lucia Sergi Sergi, Luigi Naldini, Maria Grazia Roncarolo

Research output: Contribution to journalArticlepeer-review

Abstract

Lentiviral vectors (LV) can induce type I interferon (IFN I) production from murine plasmacytoid dendritic cells (pDC), but not myeloid (my)DC. Here, we investigated whether this mechanism is conserved in human DC. MyDC and pDC were isolated from peripheral blood and transduced with increasing vector concentrations. Compared with in vitro differentiated monocyte-derived DC, the transduction efficiency of peripheral blood DC was low (ranging from

Original languageEnglish
Pages (from-to)177-188
Number of pages12
JournalHuman Gene Therapy
Volume22
Issue number2
DOIs
Publication statusPublished - Feb 1 2011

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics

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