Abstract
Lentiviral vectors (LV) can induce type I interferon (IFN I) production from murine plasmacytoid dendritic cells (pDC), but not myeloid (my)DC. Here, we investigated whether this mechanism is conserved in human DC. MyDC and pDC were isolated from peripheral blood and transduced with increasing vector concentrations. Compared with in vitro differentiated monocyte-derived DC, the transduction efficiency of peripheral blood DC was low (ranging from
Original language | English |
---|---|
Pages (from-to) | 177-188 |
Number of pages | 12 |
Journal | Human Gene Therapy |
Volume | 22 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 1 2011 |
ASJC Scopus subject areas
- Molecular Medicine
- Molecular Biology
- Genetics