HIV-1 DNA predicts disease progression and post-treatment virological control

James P. Williams; Jacob Hurst; Wolfgang Stöhr; Nicola Robinson; Helen Brown; Martin Fisher; Sabine Kinloch; David Cooper; Mauro Schechter; Giuseppe Tambussi; Sarah Fidler; Mary Carrington; Abdel Babiker; Jonathan Weber; Kersten K. Koelsch; Anthony D. Kelleher; Rodney E. Phillips; John Frater; SPARTACTrial Investigators

doi:10.7554/eLife.03821

HIV-1 DNA predicts disease progression and post-treatment virological control

James P. Williams, Jacob Hurst, Wolfgang Stöhr, Nicola Robinson, Helen Brown, Martin Fisher, Sabine Kinloch, David Cooper, Mauro Schechter, Giuseppe Tambussi, Sarah Fidler, Mary Carrington, Abdel Babiker, Jonathan Weber, Kersten K. Koelsch, Anthony D. Kelleher, Rodney E. Phillips, John Frater, SPARTACTrial Investigators

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

In HIV-1 infection, a population of latently infected cells facilitates viral persistence despite antiretroviral therapy (ART). With the aim of identifying individuals in whom ART might induce a period of viraemic control on stopping therapy, we hypothesised that quantification of the pool of latently infected cells in primary HIV-1 infection (PHI) would predict clinical progression and viral replication following ART. We measured HIV-1 DNA in a highly characterised randomised population of individuals with PHI. We explored associations between HIV-1 DNA and immunological and virological markers of clinical progression, including viral rebound in those interrupting therapy. In multivariable analyses, HIV-1 DNA was more predictive of disease progression than plasma viral load and, at treatment interruption, predicted time to plasma virus rebound. HIV-1 DNA may help identify individuals who could safely interrupt ART in future HIV-1 eradication trials.

Original language	English
Pages (from-to)	e03821
Journal	eLife
Volume	3
DOIs	https://doi.org/10.7554/eLife.03821
Publication status	Published - 2014

Keywords

antiretroviral therapy
cure
HIV-1
human
human biology
infectious disease
medicine
microbiology
primary infection
reservoir

ASJC Scopus subject areas

Neuroscience(all)
Medicine(all)
Immunology and Microbiology(all)
Biochemistry, Genetics and Molecular Biology(all)

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10.7554/eLife.03821

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Williams, J. P., Hurst, J., Stöhr, W., Robinson, N., Brown, H., Fisher, M., Kinloch, S., Cooper, D., Schechter, M., Tambussi, G., Fidler, S., Carrington, M., Babiker, A., Weber, J., Koelsch, K. K., Kelleher, A. D., Phillips, R. E., Frater, J., & SPARTACTrial Investigators (2014). HIV-1 DNA predicts disease progression and post-treatment virological control. eLife, 3, e03821. https://doi.org/10.7554/eLife.03821

Williams, JP, Hurst, J, Stöhr, W, Robinson, N, Brown, H, Fisher, M, Kinloch, S, Cooper, D, Schechter, M, Tambussi, G, Fidler, S, Carrington, M, Babiker, A, Weber, J, Koelsch, KK, Kelleher, AD, Phillips, RE, Frater, J & SPARTACTrial Investigators 2014, 'HIV-1 DNA predicts disease progression and post-treatment virological control', eLife, vol. 3, pp. e03821. https://doi.org/10.7554/eLife.03821

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abstract = "In HIV-1 infection, a population of latently infected cells facilitates viral persistence despite antiretroviral therapy (ART). With the aim of identifying individuals in whom ART might induce a period of viraemic control on stopping therapy, we hypothesised that quantification of the pool of latently infected cells in primary HIV-1 infection (PHI) would predict clinical progression and viral replication following ART. We measured HIV-1 DNA in a highly characterised randomised population of individuals with PHI. We explored associations between HIV-1 DNA and immunological and virological markers of clinical progression, including viral rebound in those interrupting therapy. In multivariable analyses, HIV-1 DNA was more predictive of disease progression than plasma viral load and, at treatment interruption, predicted time to plasma virus rebound. HIV-1 DNA may help identify individuals who could safely interrupt ART in future HIV-1 eradication trials. ",

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doi = "10.7554/eLife.03821",

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AU - Williams, James P.

AU - Hurst, Jacob

AU - Stöhr, Wolfgang

AU - Robinson, Nicola

AU - Brown, Helen

AU - Fisher, Martin

AU - Kinloch, Sabine

AU - Cooper, David

AU - Schechter, Mauro

AU - Tambussi, Giuseppe

AU - Fidler, Sarah

AU - Carrington, Mary

AU - Babiker, Abdel

AU - Weber, Jonathan

AU - Koelsch, Kersten K.

AU - Kelleher, Anthony D.

AU - Phillips, Rodney E.

AU - Frater, John

AU - SPARTACTrial Investigators

PY - 2014

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KW - cure

KW - HIV-1

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KW - human biology

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KW - microbiology

KW - primary infection

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HIV-1 DNA predicts disease progression and post-treatment virological control

Abstract

Keywords

ASJC Scopus subject areas

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