HIV-1 gp120 glycoprotein affects the astrocyte control of extracellular glutamate by both inhibiting the uptake and stimulating the release of the amino acid

Sabino Vesce, Paola Bezzi, Daniela Rossi, Jacopo Meldolesi, Andrea Volterra

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

The mechanisms of HIV-1 neurotoxicity remain still undefined although the induction of signalling events and a modest inhibition of glutamate uptake induced by the envelope glycoprotein, gp120, have called attention to astrocytes. Here we demonstrate that the levels at which the viral glycoprotein affects glutamate homeostasis of astrocyte cultures are at least two: not only the inhibition of uptake, due to an effect at site(s) away from the transporters of the amino acid but also a slow stimulation of release. The combination of these two events accounts for a considerable steady increase of the extracellular concentration of the excitatory amino acid which could play an important role in the neurotoxicity often observed in AIDS patients.

Original languageEnglish
Pages (from-to)107-109
Number of pages3
JournalFEBS Letters
Volume411
Issue number1
DOIs
Publication statusPublished - Jul 7 1997

Fingerprint

Astrocytes
HIV-1
Glutamic Acid
Glycoproteins
Amino Acid Transport Systems
Amino Acids
Excitatory Amino Acids
Acquired Immunodeficiency Syndrome
Homeostasis

Keywords

  • Astrocyte
  • Glutamate release
  • Glutamate uptake
  • gp120
  • HIV neurotoxicity

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

HIV-1 gp120 glycoprotein affects the astrocyte control of extracellular glutamate by both inhibiting the uptake and stimulating the release of the amino acid. / Vesce, Sabino; Bezzi, Paola; Rossi, Daniela; Meldolesi, Jacopo; Volterra, Andrea.

In: FEBS Letters, Vol. 411, No. 1, 07.07.1997, p. 107-109.

Research output: Contribution to journalArticle

@article{cccb18b6b62441d697d1ce3d0da4b86d,
title = "HIV-1 gp120 glycoprotein affects the astrocyte control of extracellular glutamate by both inhibiting the uptake and stimulating the release of the amino acid",
abstract = "The mechanisms of HIV-1 neurotoxicity remain still undefined although the induction of signalling events and a modest inhibition of glutamate uptake induced by the envelope glycoprotein, gp120, have called attention to astrocytes. Here we demonstrate that the levels at which the viral glycoprotein affects glutamate homeostasis of astrocyte cultures are at least two: not only the inhibition of uptake, due to an effect at site(s) away from the transporters of the amino acid but also a slow stimulation of release. The combination of these two events accounts for a considerable steady increase of the extracellular concentration of the excitatory amino acid which could play an important role in the neurotoxicity often observed in AIDS patients.",
keywords = "Astrocyte, Glutamate release, Glutamate uptake, gp120, HIV neurotoxicity",
author = "Sabino Vesce and Paola Bezzi and Daniela Rossi and Jacopo Meldolesi and Andrea Volterra",
year = "1997",
month = "7",
day = "7",
doi = "10.1016/S0014-5793(97)00674-1",
language = "English",
volume = "411",
pages = "107--109",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - HIV-1 gp120 glycoprotein affects the astrocyte control of extracellular glutamate by both inhibiting the uptake and stimulating the release of the amino acid

AU - Vesce, Sabino

AU - Bezzi, Paola

AU - Rossi, Daniela

AU - Meldolesi, Jacopo

AU - Volterra, Andrea

PY - 1997/7/7

Y1 - 1997/7/7

N2 - The mechanisms of HIV-1 neurotoxicity remain still undefined although the induction of signalling events and a modest inhibition of glutamate uptake induced by the envelope glycoprotein, gp120, have called attention to astrocytes. Here we demonstrate that the levels at which the viral glycoprotein affects glutamate homeostasis of astrocyte cultures are at least two: not only the inhibition of uptake, due to an effect at site(s) away from the transporters of the amino acid but also a slow stimulation of release. The combination of these two events accounts for a considerable steady increase of the extracellular concentration of the excitatory amino acid which could play an important role in the neurotoxicity often observed in AIDS patients.

AB - The mechanisms of HIV-1 neurotoxicity remain still undefined although the induction of signalling events and a modest inhibition of glutamate uptake induced by the envelope glycoprotein, gp120, have called attention to astrocytes. Here we demonstrate that the levels at which the viral glycoprotein affects glutamate homeostasis of astrocyte cultures are at least two: not only the inhibition of uptake, due to an effect at site(s) away from the transporters of the amino acid but also a slow stimulation of release. The combination of these two events accounts for a considerable steady increase of the extracellular concentration of the excitatory amino acid which could play an important role in the neurotoxicity often observed in AIDS patients.

KW - Astrocyte

KW - Glutamate release

KW - Glutamate uptake

KW - gp120

KW - HIV neurotoxicity

UR - http://www.scopus.com/inward/record.url?scp=0030818670&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030818670&partnerID=8YFLogxK

U2 - 10.1016/S0014-5793(97)00674-1

DO - 10.1016/S0014-5793(97)00674-1

M3 - Article

C2 - 9247152

AN - SCOPUS:0030818670

VL - 411

SP - 107

EP - 109

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 1

ER -