HIV-1 infection and hematologic picture.

M. C. Re, G. Zauli, G. Furlini, M. Giovannini, M. La Placa

Research output: Contribution to journalArticle

Abstract

This review examines the wide spectrum of hematological abnormalities frequently observed in the peripheral blood and bone marrow of HIV-1 infected subjects. Several pathogenetic mechanisms have been implicated in the derangement of the hematopoietic system occurring during the course of HIV-1 infection: imbalance of the T-cell subpopulation (CD4/CD8 ratio), altered cytokine production by infected CD4+marrow cells, production of inhibitory factors by infected marrow stromal cells, antibody-mediated suppression of hematopoietic progenitors, direct infection of hematopoetic progenitors and/or precursors, and HIV-1 mediated suppression of CD34+ cell growth in the absence of a complete viral replication cycle. Each point is considered in the text, with particular attention to the mechanisms most likely to operate in the early stages of the syndrome.

Original languageEnglish
Pages (from-to)165-176
Number of pages12
JournalMicrobiologica
Volume14
Issue number2
Publication statusPublished - Apr 1991

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HIV Infections
HIV-1
Bone Marrow
Hematopoietic System
CD4-CD8 Ratio
Stromal Cells
Cytokines
T-Lymphocytes
Antibodies
Growth
Infection

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology

Cite this

Re, M. C., Zauli, G., Furlini, G., Giovannini, M., & La Placa, M. (1991). HIV-1 infection and hematologic picture. Microbiologica, 14(2), 165-176.

HIV-1 infection and hematologic picture. / Re, M. C.; Zauli, G.; Furlini, G.; Giovannini, M.; La Placa, M.

In: Microbiologica, Vol. 14, No. 2, 04.1991, p. 165-176.

Research output: Contribution to journalArticle

Re, MC, Zauli, G, Furlini, G, Giovannini, M & La Placa, M 1991, 'HIV-1 infection and hematologic picture.', Microbiologica, vol. 14, no. 2, pp. 165-176.
Re MC, Zauli G, Furlini G, Giovannini M, La Placa M. HIV-1 infection and hematologic picture. Microbiologica. 1991 Apr;14(2):165-176.
Re, M. C. ; Zauli, G. ; Furlini, G. ; Giovannini, M. ; La Placa, M. / HIV-1 infection and hematologic picture. In: Microbiologica. 1991 ; Vol. 14, No. 2. pp. 165-176.
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