Abstract
This review examines the wide spectrum of hematological abnormalities frequently observed in the peripheral blood and bone marrow of HIV-1 infected subjects. Several pathogenetic mechanisms have been implicated in the derangement of the hematopoietic system occurring during the course of HIV-1 infection: imbalance of the T-cell subpopulation (CD4/CD8 ratio), altered cytokine production by infected CD4+marrow cells, production of inhibitory factors by infected marrow stromal cells, antibody-mediated suppression of hematopoietic progenitors, direct infection of hematopoetic progenitors and/or precursors, and HIV-1 mediated suppression of CD34+ cell growth in the absence of a complete viral replication cycle. Each point is considered in the text, with particular attention to the mechanisms most likely to operate in the early stages of the syndrome.
| Original language | English |
|---|---|
| Pages (from-to) | 165-176 |
| Number of pages | 12 |
| Journal | Microbiologica |
| Volume | 14 |
| Issue number | 2 |
| Publication status | Published - Apr 1991 |
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ASJC Scopus subject areas
- Applied Microbiology and Biotechnology
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HIV-1 infection and hematologic picture. / Re, M. C.; Zauli, G.; Furlini, G.; Giovannini, M.; La Placa, M.
In: Microbiologica, Vol. 14, No. 2, 04.1991, p. 165-176.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - HIV-1 infection and hematologic picture.
AU - Re, M. C.
AU - Zauli, G.
AU - Furlini, G.
AU - Giovannini, M.
AU - La Placa, M.
PY - 1991/4
Y1 - 1991/4
N2 - This review examines the wide spectrum of hematological abnormalities frequently observed in the peripheral blood and bone marrow of HIV-1 infected subjects. Several pathogenetic mechanisms have been implicated in the derangement of the hematopoietic system occurring during the course of HIV-1 infection: imbalance of the T-cell subpopulation (CD4/CD8 ratio), altered cytokine production by infected CD4+marrow cells, production of inhibitory factors by infected marrow stromal cells, antibody-mediated suppression of hematopoietic progenitors, direct infection of hematopoetic progenitors and/or precursors, and HIV-1 mediated suppression of CD34+ cell growth in the absence of a complete viral replication cycle. Each point is considered in the text, with particular attention to the mechanisms most likely to operate in the early stages of the syndrome.
AB - This review examines the wide spectrum of hematological abnormalities frequently observed in the peripheral blood and bone marrow of HIV-1 infected subjects. Several pathogenetic mechanisms have been implicated in the derangement of the hematopoietic system occurring during the course of HIV-1 infection: imbalance of the T-cell subpopulation (CD4/CD8 ratio), altered cytokine production by infected CD4+marrow cells, production of inhibitory factors by infected marrow stromal cells, antibody-mediated suppression of hematopoietic progenitors, direct infection of hematopoetic progenitors and/or precursors, and HIV-1 mediated suppression of CD34+ cell growth in the absence of a complete viral replication cycle. Each point is considered in the text, with particular attention to the mechanisms most likely to operate in the early stages of the syndrome.
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M3 - Article
C2 - 1857267
AN - SCOPUS:0026148912
VL - 14
SP - 165
EP - 176
JO - Microbiologica
JF - Microbiologica
SN - 0391-5352
IS - 2
ER -