HIV and decreased risk of multiple sclerosis

role of low CD4+ lymphocyte count and male prevalence

Tatiana Koudriavtseva, Domenico Plantone, Chiara Mandoj, Diana Giannarelli, Alessandra Latini, Manuela Colafigli, Elisabetta Trento, Paola Cordiali Fei, Fulvia Pimpinelli

Research output: Contribution to journalArticle

Abstract

In this retrospective case-control study, we compared the number of circulating lymphocyte subsets among 31 healthy controls, 18 naïve and 40 antiretroviral-treated HIV patients, 28 untreated and 18 treated relapsing-remitting multiple sclerosis (MS) patients. Lymphocyte subsets were no different between untreated MS patients and controls. Untreated and treated MS had a lower CD8+ count and a higher CD4+ number compared to untreated and treated HIV patients except similar CD4+ number between treated MS and HIV patients. CD4/CD8 ratio was lower in female HIV non-responders and in relapsing MS women compared, respectively, to female HIV responders and remitting MS women, and there were no differences in men.

Original languageEnglish
Pages (from-to)147-151
JournalJournal of NeuroVirology
Volume23
Issue number1
DOIs
Publication statusPublished - Feb 2017

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CD4 Lymphocyte Count
Multiple Sclerosis
HIV
Lymphocyte Subsets
Relapsing-Remitting Multiple Sclerosis
CD4-CD8 Ratio
Case-Control Studies

Keywords

  • CD4+ count
  • circulating lymphocytes
  • gender
  • HIV positive dermatological patients
  • Multiple Sclerosis

ASJC Scopus subject areas

  • Virology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Neurology

Cite this

HIV and decreased risk of multiple sclerosis : role of low CD4+ lymphocyte count and male prevalence. / Koudriavtseva, Tatiana; Plantone, Domenico; Mandoj, Chiara; Giannarelli, Diana; Latini, Alessandra; Colafigli, Manuela; Trento, Elisabetta; Cordiali Fei, Paola; Pimpinelli, Fulvia.

In: Journal of NeuroVirology, Vol. 23, No. 1, 02.2017, p. 147-151.

Research output: Contribution to journalArticle

Koudriavtseva, Tatiana ; Plantone, Domenico ; Mandoj, Chiara ; Giannarelli, Diana ; Latini, Alessandra ; Colafigli, Manuela ; Trento, Elisabetta ; Cordiali Fei, Paola ; Pimpinelli, Fulvia. / HIV and decreased risk of multiple sclerosis : role of low CD4+ lymphocyte count and male prevalence. In: Journal of NeuroVirology. 2017 ; Vol. 23, No. 1. pp. 147-151.
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