HIV and decreased risk of multiple sclerosis: role of low CD4+ lymphocyte count and male prevalence

Tatiana Koudriavtseva, Domenico Plantone, Chiara Mandoj, Diana Giannarelli, Alessandra Latini, Manuela Colafigli, Elisabetta Trento, Paola Cordiali Fei, Fulvia Pimpinelli

Research output: Contribution to journalArticle

Abstract

In this retrospective case-control study, we compared the number of circulating lymphocyte subsets among 31 healthy controls, 18 naïve and 40 antiretroviral-treated HIV patients, 28 untreated and 18 treated relapsing-remitting multiple sclerosis (MS) patients. Lymphocyte subsets were no different between untreated MS patients and controls. Untreated and treated MS had a lower CD8+ count and a higher CD4+ number compared to untreated and treated HIV patients except similar CD4+ number between treated MS and HIV patients. CD4/CD8 ratio was lower in female HIV non-responders and in relapsing MS women compared, respectively, to female HIV responders and remitting MS women, and there were no differences in men.

Original languageEnglish
Pages (from-to)147-151
JournalJournal of NeuroVirology
Volume23
Issue number1
DOIs
Publication statusPublished - Feb 2017

Keywords

  • CD4+ count
  • circulating lymphocytes
  • gender
  • HIV positive dermatological patients
  • Multiple Sclerosis

ASJC Scopus subject areas

  • Virology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Neurology

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