HIV and decreased risk of multiple sclerosis: role of low CD4+ lymphocyte count and male prevalence

T. Koudriavtseva, D. Plantone, C. Mandoj, D. Giannarelli, A. Latini, M. Colafigli, E. Trento, P. Cordiali-Fei, F. Pimpinelli

Research output: Contribution to journalArticlepeer-review

Abstract

In this retrospective case-control study, we compared the number of circulating lymphocyte subsets among 31 healthy controls, 18 naive and 40 antiretroviral-treated HIV patients, 28 untreated and 18 treated relapsing-remitting multiple sclerosis (MS) patients. Lymphocyte subsets were no different between untreated MS patients and controls. Untreated and treated MS had a lower CD8+ count and a higher CD4+ number compared to untreated and treated HIV patients except similar CD4+ number between treated MS and HIV patients. CD4/CD8 ratio was lower in female HIV non-responders and in relapsing MS women compared, respectively, to female HIV responders and remitting MS women, and there were no differences in men.
Original languageEnglish
Pages (from-to)147-151
Number of pages5
JournalJournal of NeuroVirology
Volume23
Issue number1
DOIs
Publication statusPublished - Feb 1 2017

Keywords

  • CD4+ count
  • HIV positive dermatological patients
  • Multiple Sclerosis
  • circulating lymphocytes
  • gender

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