HIV DNA loads, plasma residual viraemia and risk of virological rebound in heavily treated, virologically suppressed HIV-infected patients

N. Gianotti, F. Canducci, L. Galli, F. Cossarini, S. Salpietro, A. Poli, S. Nozza, V. Spagnuolo, M. Clementi, M. Sampaolo, E. R. Ceresola, S. Racca, A. Lazzarin, A. Castagna

Research output: Contribution to journalArticlepeer-review

Abstract

In this single-centre, retrospective study, we analyzed data of 194 patients receiving antiretroviral therapy with 6 peripheral blood lymphocytes (PBL), and HIV DNA loads were independently associated with residual viraemia (p0.002). Virological rebound occurred in 29/194 (15%) patients over a median (interquartile range) follow-up of 17.5 (13.5-31.5) months. Residual viraemia (p 0.002), but not HIV DNA load, was independently associated with virological rebound.

Original languageEnglish
Pages (from-to)103.e7-103.e10
JournalClinical Microbiology and Infection
Volume21
Issue number1
DOIs
Publication statusPublished - 2015

Keywords

  • HIV-1 DNA load
  • KPCR
  • Residual viraemia
  • Virological failure
  • Virological rebound

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Medicine(all)

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