HIV DNA loads, plasma residual viraemia and risk of virological rebound in heavily treated, virologically suppressed HIV-infected patients

N. Gianotti, F. Canducci, L. Galli, F. Cossarini, S. Salpietro, A. Poli, S. Nozza, V. Spagnuolo, M. Clementi, M. Sampaolo, E. R. Ceresola, S. Racca, A. Lazzarin, A. Castagna

Research output: Contribution to journalArticle

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Abstract

In this single-centre, retrospective study, we analyzed data of 194 patients receiving antiretroviral therapy with 6 peripheral blood lymphocytes (PBL), and HIV DNA loads were independently associated with residual viraemia (p0.002). Virological rebound occurred in 29/194 (15%) patients over a median (interquartile range) follow-up of 17.5 (13.5-31.5) months. Residual viraemia (p 0.002), but not HIV DNA load, was independently associated with virological rebound.

Original languageEnglish
Pages (from-to)103.e7-103.e10
JournalClinical Microbiology and Infection
Volume21
Issue number1
DOIs
Publication statusPublished - 2015

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Viremia
HIV
DNA
Retrospective Studies
Lymphocytes
Therapeutics

Keywords

  • HIV-1 DNA load
  • KPCR
  • Residual viraemia
  • Virological failure
  • Virological rebound

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Medicine(all)

Cite this

HIV DNA loads, plasma residual viraemia and risk of virological rebound in heavily treated, virologically suppressed HIV-infected patients. / Gianotti, N.; Canducci, F.; Galli, L.; Cossarini, F.; Salpietro, S.; Poli, A.; Nozza, S.; Spagnuolo, V.; Clementi, M.; Sampaolo, M.; Ceresola, E. R.; Racca, S.; Lazzarin, A.; Castagna, A.

In: Clinical Microbiology and Infection, Vol. 21, No. 1, 2015, p. 103.e7-103.e10.

Research output: Contribution to journalArticle

Gianotti, N. ; Canducci, F. ; Galli, L. ; Cossarini, F. ; Salpietro, S. ; Poli, A. ; Nozza, S. ; Spagnuolo, V. ; Clementi, M. ; Sampaolo, M. ; Ceresola, E. R. ; Racca, S. ; Lazzarin, A. ; Castagna, A. / HIV DNA loads, plasma residual viraemia and risk of virological rebound in heavily treated, virologically suppressed HIV-infected patients. In: Clinical Microbiology and Infection. 2015 ; Vol. 21, No. 1. pp. 103.e7-103.e10.
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AU - Poli, A.

AU - Nozza, S.

AU - Spagnuolo, V.

AU - Clementi, M.

AU - Sampaolo, M.

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