HIV-infected patients show impaired cellular immune response to influenza vaccination compared to healthy subjects

Massimiliano Fabbiani, Letizia Sidella, Maddalena Corbi, Rosa Martucci, Michela Sali, Manuela Colafigli, Roberto Cauda, Giovanni Delogu, Alessandro Sgambato, Simona Di Giambenedetto

Research output: Contribution to journalArticle

Abstract

Detailed data on cellular immune response to influenza vaccination in HIV-infected patients are lacking. We analyzed cellular (IL-2, IL-4, IL-5, IL-10, IL-12, IL-13, IFN-γ, TNF-α, GM-CSF) and humoral (IgG and IgM) immune response in 81 HIV-infected and 30 HIV-negative subjects, before (T0) and 4 weeks (T1) after receiving a single dose of trivalent MF59-adjuvanted influenza vaccine. No difference in humoral response (IgG or IgM) was demonstrated between the two groups. While an increase in most cytokines from T0 to T1 was observed in HIV-uninfected subjects, cytokines production did not significantly increased in HIV-infected patients. Exploring Th1 response, higher CD8 cells count was significantly associated with lower post-vaccination IFNγ levels, while a higher CD4 cells count was associated with a greater response. Exploring Th2 response, higher HIV viral load was significantly associated with reduced post-vaccination IL-10 levels. In conclusion, in HIV-infected patients influenza vaccination could have good efficacy in sustaining humoral response but cellular response appeared impaired.

Original languageEnglish
Pages (from-to)2914-2918
Number of pages5
JournalVaccine
Volume31
Issue number28
DOIs
Publication statusPublished - Jun 19 2013

    Fingerprint

Keywords

  • Cellular immune response
  • HIV
  • Humoral immune response
  • Immunogenicity
  • Influenza
  • Vaccination

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)
  • Molecular Medicine

Cite this

Fabbiani, M., Sidella, L., Corbi, M., Martucci, R., Sali, M., Colafigli, M., Cauda, R., Delogu, G., Sgambato, A., & Di Giambenedetto, S. (2013). HIV-infected patients show impaired cellular immune response to influenza vaccination compared to healthy subjects. Vaccine, 31(28), 2914-2918. https://doi.org/10.1016/j.vaccine.2013.04.033