Abstract
Therapeutical strategies aimed to the maximal inhibition (if not the eradication) of infection by human immunodeficiency virus should take into account the issue of the viral reservoir in the body. Recent data clearly show that latently infected lymphocytes represent a minimal part of the viral reservoir, while the majority of these cells are macrophages (variably differentiated) scattered in the tissues and lymph nodes. Immunologically-sequestrated areas, such as the central nervous system, are particularly relevant in view of the different concentrations of antiviral drugs achieved in the organs. Thus, a careful analysis of the distribution of antiviral drugs, and the assessment of their activity in cells of macrophage lineage, represent key factors in the development of therapeutical strategies aimed to the 'cure' of infectious patients.
| Original language | English |
|---|---|
| Pages (from-to) | 69-73 |
| Number of pages | 5 |
| Journal | Journal of Biological Regulators and Homeostatic Agents |
| Volume | 11 |
| Issue number | 1-2 |
| Publication status | Published - Jan 1997 |
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Keywords
- AIDS dementia complex
- Anti-viral therapy
- Central nervous system
- HIV-reservoir
- Protease inhibitors
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Endocrinology
- Physiology
- Immunology
- Medicine (miscellaneous)
- Endocrinology, Diabetes and Metabolism
- Physiology (medical)
Cite this
HIV infection in macrophage : Role of long-lived cells and related therapeutical strategies. / Aquaro, S.; Balestra, E.; Cenci, A.; Francesconi, M.; Caliò, R.; Perno, C. F.
In: Journal of Biological Regulators and Homeostatic Agents, Vol. 11, No. 1-2, 01.1997, p. 69-73.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - HIV infection in macrophage
T2 - Role of long-lived cells and related therapeutical strategies
AU - Aquaro, S.
AU - Balestra, E.
AU - Cenci, A.
AU - Francesconi, M.
AU - Caliò, R.
AU - Perno, C. F.
PY - 1997/1
Y1 - 1997/1
N2 - Therapeutical strategies aimed to the maximal inhibition (if not the eradication) of infection by human immunodeficiency virus should take into account the issue of the viral reservoir in the body. Recent data clearly show that latently infected lymphocytes represent a minimal part of the viral reservoir, while the majority of these cells are macrophages (variably differentiated) scattered in the tissues and lymph nodes. Immunologically-sequestrated areas, such as the central nervous system, are particularly relevant in view of the different concentrations of antiviral drugs achieved in the organs. Thus, a careful analysis of the distribution of antiviral drugs, and the assessment of their activity in cells of macrophage lineage, represent key factors in the development of therapeutical strategies aimed to the 'cure' of infectious patients.
AB - Therapeutical strategies aimed to the maximal inhibition (if not the eradication) of infection by human immunodeficiency virus should take into account the issue of the viral reservoir in the body. Recent data clearly show that latently infected lymphocytes represent a minimal part of the viral reservoir, while the majority of these cells are macrophages (variably differentiated) scattered in the tissues and lymph nodes. Immunologically-sequestrated areas, such as the central nervous system, are particularly relevant in view of the different concentrations of antiviral drugs achieved in the organs. Thus, a careful analysis of the distribution of antiviral drugs, and the assessment of their activity in cells of macrophage lineage, represent key factors in the development of therapeutical strategies aimed to the 'cure' of infectious patients.
KW - AIDS dementia complex
KW - Anti-viral therapy
KW - Central nervous system
KW - HIV-reservoir
KW - Protease inhibitors
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UR - http://www.scopus.com/inward/citedby.url?scp=0030828620&partnerID=8YFLogxK
M3 - Article
VL - 11
SP - 69
EP - 73
JO - Journal of Biological Regulators and Homeostatic Agents
JF - Journal of Biological Regulators and Homeostatic Agents
SN - 0393-974X
IS - 1-2
ER -