HIV infection in macrophage: Role of long-lived cells and related therapeutical strategies

S. Aquaro, E. Balestra, A. Cenci, M. Francesconi, R. Caliò, C. F. Perno

Research output: Contribution to journalArticlepeer-review


Therapeutical strategies aimed to the maximal inhibition (if not the eradication) of infection by human immunodeficiency virus should take into account the issue of the viral reservoir in the body. Recent data clearly show that latently infected lymphocytes represent a minimal part of the viral reservoir, while the majority of these cells are macrophages (variably differentiated) scattered in the tissues and lymph nodes. Immunologically-sequestrated areas, such as the central nervous system, are particularly relevant in view of the different concentrations of antiviral drugs achieved in the organs. Thus, a careful analysis of the distribution of antiviral drugs, and the assessment of their activity in cells of macrophage lineage, represent key factors in the development of therapeutical strategies aimed to the 'cure' of infectious patients.

Original languageEnglish
Pages (from-to)69-73
Number of pages5
JournalJournal of Biological Regulators and Homeostatic Agents
Issue number1-2
Publication statusPublished - Jan 1997


  • AIDS dementia complex
  • Anti-viral therapy
  • Central nervous system
  • HIV-reservoir
  • Protease inhibitors

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Endocrinology
  • Physiology
  • Immunology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Physiology (medical)


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