HIV mother-to-child transmission: A complex genetic puzzle tackled by Brazil and Argentina research teams

R. Celerino da Silva, E. Bedin, A. Mangano, P. Aulicino, A. Pontillo, L. Brandão, R. Guimarães, L. C. Arraes, L. Sen, S. Crovella

Research output: Contribution to journalArticle

Abstract

Human immunodeficiency virus (HIV) mother-to-child transmission is a complex event, depending upon environmental factors and is affected by host genetic factors from mother and child, as well as viral genetic elements. The integration of multiple parameters (CD4 cell count, virus load, HIV subtype, and host genetic markers) could account for the susceptibility to HIV infection, a multifactorial trait. The goal of this manuscript is to analyze the immunogenetic factors associated to HIV mother-to-child transmission, trying to unravel the genetic puzzle of HIV mother-to-child transmission and considering the experience in this topic of two research groups from Brazil and Argentina.

Original languageEnglish
Pages (from-to)312-322
Number of pages11
JournalInfection, Genetics and Evolution
Volume19
DOIs
Publication statusPublished - Oct 2013

Keywords

  • HIV
  • Host genome
  • Immunogenetics markers
  • Mother-to-child transmission
  • Protection
  • Susceptibility

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Molecular Biology
  • Microbiology
  • Infectious Diseases
  • Microbiology (medical)

Fingerprint Dive into the research topics of 'HIV mother-to-child transmission: A complex genetic puzzle tackled by Brazil and Argentina research teams'. Together they form a unique fingerprint.

  • Cite this

    da Silva, R. C., Bedin, E., Mangano, A., Aulicino, P., Pontillo, A., Brandão, L., Guimarães, R., Arraes, L. C., Sen, L., & Crovella, S. (2013). HIV mother-to-child transmission: A complex genetic puzzle tackled by Brazil and Argentina research teams. Infection, Genetics and Evolution, 19, 312-322. https://doi.org/10.1016/j.meegid.2013.03.005