HIV-particles in spermatozoa of patients with AIDS and their transfer into the oocyte

Baccio Baccetti, Arrigo Benedetto, Anna G. Burrini, Giulia Collodel, Elvira Costantino Ceccarini, Nicla Crisà, Antonino Di Caro, Mariela Estenoz, Anna R. Garbuglia, Adina Massacesi, Paola Piomboni, Tommaso Renieri, Delia Solazzo

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Abstract

By immunocytochemistry and in situ hybridization at the electron microscopy level, and by the PCR technique, we have shown that HIV-1 binds and enters normal sperm; that viral particles, their antigens, and nucleic acid are present in sperm from HIV-1 infected men; and that such sperm can transfer HIV-1 like particles to normal human oocytes. We also present evidence that a galactosylceramide-like compound is present on the sperm membrane and could function as an alternative receptor for HIV.

Original languageEnglish
Pages (from-to)903-914
Number of pages12
JournalJournal of Cell Biology
Volume127
Issue number4
DOIs
Publication statusPublished - Nov 1994

ASJC Scopus subject areas

  • Cell Biology

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    Baccetti, B., Benedetto, A., Burrini, A. G., Collodel, G., Ceccarini, E. C., Crisà, N., Di Caro, A., Estenoz, M., Garbuglia, A. R., Massacesi, A., Piomboni, P., Renieri, T., & Solazzo, D. (1994). HIV-particles in spermatozoa of patients with AIDS and their transfer into the oocyte. Journal of Cell Biology, 127(4), 903-914. https://doi.org/10.1083/jcb.127.4.903