HIV-related malignant lymphoma: A report of 46 cases observed in Italy

U. Tirelli, E. Vaccher, A. Ambrosini, A. Andriani, I. Bianco Silvestroni, G. Broccia, T. Chisesi, P. Dessalvi, M. Gobbi, F. Fassio, G. Lambertenghi Deliliers, F. Lanza, A. Lazzarin, F. Lombardi, G. Luzi, C. Malleo, E. A. Parrinello, R. Proto, F. Puppo, G. RezzaG. Rossi, F. Gavosto, S. Monfardini

Research output: Contribution to journalArticlepeer-review


We report 36 patients with non-Hodgkin’s lymphomas (NHL) and 10 patients with Hodgkin’s disease (HD), predominantly intravenous drug abusers (IVDA; 35 patients), diagnosed in 16 different Italian centers. The group of NHL has a median age of 26 years (range 16-64): 26 were IVDA, 3 polytransfused, 3 IVDA and homosexual men, 2 homosexual men and 2 without apparent risk for AIDS but carrying HIV antibodies. 81% of the evaluable patients had high-grade NHL (32% Burkitt’s type) according to the Working Formulation, 15% intermediate and 4% low-grade. Out of 23 patients with stage reported, 16 (70%) were stage IV, 2 (9%) stage III, 1 (4%) stage II and 4(17%) stage I (CNS involvement). The group with HD has a median age of 25 years (range 20-40), 9 were IVDA and 1 IVDA and homosexual. Of the 7 patients with subtype reported, 4 patients had nodular sclerosis and 3 mixed cellularity subtype. Stage III and IV were reported in 66% of the patients. The median survival is 4 months for NHL and 10 months for HD. The most common cause of death is opportunistic infection in 86% of the evaluable cases.

Original languageEnglish
Pages (from-to)49-51
Number of pages3
JournalActa Haematologica
Issue number1
Publication statusPublished - 1988


  • Acquired immunodeficiency syndrome
  • HIV-related malignant lymphomas
  • Malignant lymphomas

ASJC Scopus subject areas

  • Hematology


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