I linfomi non Hodgkin-HIV sistemici nell'era dell'HAART. Storia naturale

Translated title of the contribution: HIV-related NHL in the HAART era. Natural history

Senka Juzbasic, Michele Spina, Emanuela Vaccher, Umberto Tirelli

Research output: Contribution to journalArticlepeer-review

Abstract

In the era of highly active antiretroviral therapy (HAART), systemic non-Hodgkin lymphoma (NHL) represented the most frequent cancer associated to HIV infection. In contrast to Kaposi's sarcoma and primary central nervous system lymphoma (PCNSL) wich incidence have been declining after introduction of HAART, systemic NHL-HIV has relatively stable remaind. Systemic HIV related NHL are markedly heterogeneous both histologically and clinically and this clinicophatological heterogenity reflects variability in the molecular lesions associated to these lymphomas and immunological status of these patients. The introduction of HAART has substantially modified the approach to HIV related lymphomas. The results of recent monoinstitutional study of Aviano Cancer's Institute on 235 patients have suggested that HAART would otherwise allow a long life expectancy with longer disease free survival and overall survival. In fact the reduced of morbidity of AIDS patients bought by HAART justified the use of aggressive antineoplastic therapies.

Translated title of the contributionHIV-related NHL in the HAART era. Natural history
Original languageItalian
Pages (from-to)676-689
Number of pages14
JournalRecenti Progressi in Medicina
Volume92
Issue number11
Publication statusPublished - Nov 2001

ASJC Scopus subject areas

  • Medicine(all)

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