Abstract
Severe thrombocytopenia (TP) accounted for 5.3% of cases in a consecutive series of 380 HIV-infected intravenous drug users (IVDUs) at presentation. Forty-one of 53 subjects with severe TP showed haemorrhages and were treated as follows: ten were splenectomized, 17 were given high-dose intravenous immunoglobulins (HDIg), and 10 received anti-Rh(D) immunoglobulins (anti-Rh Ig). Splenectomy induced a complete clinical response in all cases: four out of 10 patients maintained platelet counts >100 × 109/I. HDIg gave a good clinical response in all patients, but eight out of 17 suffered haemorrhages during the follow-up and recall treatments were necessary. Six out of 10 patients treated with anti-Rh Ig maintained platelet counts >30 × 109/I, but in two cases the treatment was interrupted because of severe haemolysis. No patient progressed to overt AIDS during the follow-up. Splenectomized patients in particular did not show adjunctive risks of worsening of the HIV-related clinical picture. A platelet kinetic study performed in 20 patients with severe HIV-related TP suggests a possible role for platelet sequestration in TP of HIV-infected IVDUs, in which a liver involvement is very frequent.
| Original language | English |
|---|---|
| Pages (from-to) | 29-34 |
| Number of pages | 6 |
| Journal | AIDS (London, England) |
| Volume | 4 |
| Issue number | 1 |
| Publication status | Published - 1990 |
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Keywords
- Anti-Rh(D) immunoglobulins
- High-dose immunoglobulins
- Intravenous drug users
- Platelet kinetic study
- Severe HIV-related thrombocytopenia
- Splenectomy
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
HIV-related severe thrombocytopenia in intravenous drug users : Prevalence, response to therapy in a medium-term follow-up, and pathogenetic evaluation. / Landonio, Giuseppe; Galli, Massimo; Nosari, Annamaria; Lazzarin, Adriano; Cipriani, Dino; Crocchiolo, Paolo; Voltolin, Luca; Giannelli, Fabio; Irato, Laura; De Cataldo, Francesco; Moroni, Mauro.
In: AIDS (London, England), Vol. 4, No. 1, 1990, p. 29-34.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - HIV-related severe thrombocytopenia in intravenous drug users
T2 - Prevalence, response to therapy in a medium-term follow-up, and pathogenetic evaluation
AU - Landonio, Giuseppe
AU - Galli, Massimo
AU - Nosari, Annamaria
AU - Lazzarin, Adriano
AU - Cipriani, Dino
AU - Crocchiolo, Paolo
AU - Voltolin, Luca
AU - Giannelli, Fabio
AU - Irato, Laura
AU - De Cataldo, Francesco
AU - Moroni, Mauro
PY - 1990
Y1 - 1990
N2 - Severe thrombocytopenia (TP) accounted for 5.3% of cases in a consecutive series of 380 HIV-infected intravenous drug users (IVDUs) at presentation. Forty-one of 53 subjects with severe TP showed haemorrhages and were treated as follows: ten were splenectomized, 17 were given high-dose intravenous immunoglobulins (HDIg), and 10 received anti-Rh(D) immunoglobulins (anti-Rh Ig). Splenectomy induced a complete clinical response in all cases: four out of 10 patients maintained platelet counts >100 × 109/I. HDIg gave a good clinical response in all patients, but eight out of 17 suffered haemorrhages during the follow-up and recall treatments were necessary. Six out of 10 patients treated with anti-Rh Ig maintained platelet counts >30 × 109/I, but in two cases the treatment was interrupted because of severe haemolysis. No patient progressed to overt AIDS during the follow-up. Splenectomized patients in particular did not show adjunctive risks of worsening of the HIV-related clinical picture. A platelet kinetic study performed in 20 patients with severe HIV-related TP suggests a possible role for platelet sequestration in TP of HIV-infected IVDUs, in which a liver involvement is very frequent.
AB - Severe thrombocytopenia (TP) accounted for 5.3% of cases in a consecutive series of 380 HIV-infected intravenous drug users (IVDUs) at presentation. Forty-one of 53 subjects with severe TP showed haemorrhages and were treated as follows: ten were splenectomized, 17 were given high-dose intravenous immunoglobulins (HDIg), and 10 received anti-Rh(D) immunoglobulins (anti-Rh Ig). Splenectomy induced a complete clinical response in all cases: four out of 10 patients maintained platelet counts >100 × 109/I. HDIg gave a good clinical response in all patients, but eight out of 17 suffered haemorrhages during the follow-up and recall treatments were necessary. Six out of 10 patients treated with anti-Rh Ig maintained platelet counts >30 × 109/I, but in two cases the treatment was interrupted because of severe haemolysis. No patient progressed to overt AIDS during the follow-up. Splenectomized patients in particular did not show adjunctive risks of worsening of the HIV-related clinical picture. A platelet kinetic study performed in 20 patients with severe HIV-related TP suggests a possible role for platelet sequestration in TP of HIV-infected IVDUs, in which a liver involvement is very frequent.
KW - Anti-Rh(D) immunoglobulins
KW - High-dose immunoglobulins
KW - Intravenous drug users
KW - Platelet kinetic study
KW - Severe HIV-related thrombocytopenia
KW - Splenectomy
UR - http://www.scopus.com/inward/record.url?scp=0025164735&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025164735&partnerID=8YFLogxK
M3 - Article
C2 - 2156528
AN - SCOPUS:0025164735
VL - 4
SP - 29
EP - 34
JO - AIDS
JF - AIDS
SN - 0269-9370
IS - 1
ER -