HIV replication leads to skewed maturation of CD8-positive T-cell responses in infected children

Carla Montesano, Alessia Anselmi, Paolo Palma, Stefania Bernardi, Rosella Cicconi, Maurizio Mattei, Guido Castelli-Gattinara, Massimo Ciccozzi, Vittorio Colizzi, Massimo Amicosante

Research output: Contribution to journalArticlepeer-review

Abstract

HIV-1 infection causes a severe T-cell impairment with alteration of immune response. However, in children the natural decline of lymphocytes and CD4 cells in early life makes it more difficult to monitor immunocompetence and progression of HIV-infection. Aim of this study was to characterize the CD8 response in non-vertically HIV-infected children exposed persistently to viremia and in HIV-infected children controlling efficiently viremia by ART, by analysing the effect of persistent viremia on CD4 and CD8 T-cells count, HIV-specific immune-response and naive/memory pattern of CD8 T-cell. Whereas, no differences of CD4 count between viremic patients and viral controllers were observed (1046.9±472.1 cells/pl vs 1101.3±415.4 cells/μl; p>0.05), CD8 count was higher in the viremic patients (1080.6±652.1 cells/pl vs 747.5±389.9 cells/pl, p

Original languageEnglish
Pages (from-to)303-309
Number of pages7
JournalNew Microbiologica
Volume33
Issue number4
Publication statusPublished - Oct 2010

Keywords

  • Children
  • Hiv-specific immune response
  • Naï
  • Ve/memory lymphocytes

ASJC Scopus subject areas

  • Microbiology (medical)

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