HIV shedding in cervico-vaginal secretions in pregnant women

Barbara Gardella, Marianna Roccio, Anna Maccabruni, Bianca Mariani, Lucia Panzeri, Francesca Zara, Arsenio Spinillo

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The purpose of this study was to evaluate the presence of HIV-1 in cervico-vaginal secretions of pregnant as compared to non-pregnant HIV-seropositive women. Patients and Methods: We compared 43 known HIV seropositive pregnant patients versus 241 age-matched (± 2 years) control non-pregnant HIV-seropositive subjects. In pregnant patients blood and cervico-vaginal samples were obtained during each trimester of pregnancy. In control subjects the same samples were obtained at enrolment. HIV-1 RNA was measured in plasma; proviral HIV-1 DNA, cell-associated and cell-free HIV-1 RNA in cervico-vaginal secretion by competitive polymerase chain reaction (cRT-PCR) and reverse transcriptase PCR. Results: The genital shedding of HIV-DNA (22/43 as compared to 79/241, p = 0.02), and cell-free HIV-RNA detection (26/43 as compared to 72/241, p

Original languageEnglish
Pages (from-to)313-320
Number of pages8
JournalCurrent HIV Research
Volume9
Issue number5
DOIs
Publication statusPublished - 2011

Keywords

  • Cervico-vaginal secretions
  • HIV shedding
  • Nucleic acids
  • Vertical transmission

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

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