Hiv-specific secretory IgA in breast milk of HIV-positive mothers is not associated with protection against HIV transmission among breast-fed infants

Louise Kuhn, Daria Trabattoni, Chipepo Kankasa, Moses Sinkala, Francesca Lissoni, Mrinal Ghosh, Grace Aldrovandi, Don Thea, Mario Clerici

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Objectives: To test whether secretory immunoglobulin A (sIgA) to human immunodeficiency virus (HIV) antigens in breast milk of HIV-positive women is associated with protection against HIV transmission among breast-fed infants. Study design: Nested, case-control design in which HIV-specific sIgA was measured in breast milk collected from 90 HIV-positive women enrolled in a study in Lusaka, Zambia. Milk samples were selected to include 26 HIV-positive mothers with infected infants (transmitters) and 64 mothers with uninfected infants (nontransmitters). Results: HIV-specific sIgA was detected more often in breast milk of transmitting mothers (76.9%) than in breast milk of nontransmitting mothers (46.9%, P = .009). There were no significant associations between HIV-specific sIgA in breast milk and other maternal factors, including HIV RNA quantities in breast milk, CD4 count, and plasma RNA quantities. Conclusions: HIV-specific sIgA in breast milk does not appear to be a protective factor against HIV transmission among breast-fed infants.

Original languageEnglish
Pages (from-to)611-616
Number of pages6
JournalJournal of Pediatrics
Volume149
Issue number5
DOIs
Publication statusPublished - Nov 2006

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Secretory Immunoglobulin A
Human Milk
Breast
Mothers
HIV
RNA
Zambia
CD4 Lymphocyte Count
Case-Control Studies
Milk

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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Hiv-specific secretory IgA in breast milk of HIV-positive mothers is not associated with protection against HIV transmission among breast-fed infants. / Kuhn, Louise; Trabattoni, Daria; Kankasa, Chipepo; Sinkala, Moses; Lissoni, Francesca; Ghosh, Mrinal; Aldrovandi, Grace; Thea, Don; Clerici, Mario.

In: Journal of Pediatrics, Vol. 149, No. 5, 11.2006, p. 611-616.

Research output: Contribution to journalArticle

Kuhn, Louise ; Trabattoni, Daria ; Kankasa, Chipepo ; Sinkala, Moses ; Lissoni, Francesca ; Ghosh, Mrinal ; Aldrovandi, Grace ; Thea, Don ; Clerici, Mario. / Hiv-specific secretory IgA in breast milk of HIV-positive mothers is not associated with protection against HIV transmission among breast-fed infants. In: Journal of Pediatrics. 2006 ; Vol. 149, No. 5. pp. 611-616.
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AU - Trabattoni, Daria

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AU - Sinkala, Moses

AU - Lissoni, Francesca

AU - Ghosh, Mrinal

AU - Aldrovandi, Grace

AU - Thea, Don

AU - Clerici, Mario

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