HIV subtypes and recombination strains-strategies for induction of immune responses in man

B. Wahren; K. Ljungberg; E. Rollman; M. Levi; B. Zuber; A. Kjerrström Zuber; J. Hinkula; A. C. Leandersson; S. Calarota; B. Hejdeman; G. Bratt; E. Sandström

doi:10.1016/S0264-410X(02)00084-1

HIV subtypes and recombination strains-strategies for induction of immune responses in man

B. Wahren, K. Ljungberg, E. Rollman, M. Levi, B. Zuber, A. Kjerrström Zuber, J. Hinkula, A. C. Leandersson, S. Calarota, B. Hejdeman, G. Bratt, E. Sandström

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

Clinical and experimental studies of HIV-1 subcomponents were made in order to increase their immunogenicity. HIV subtype envelopes A, B and C have been compared and a detailed analysis made by peptides of the coreceptor-ligand interactions. We identified a direct interaction between HIV-1 envelope and a cellular receptor at the amino acid level. Both the viral subtype and its tropism appeared to influence inhibition of infection. Genetic immunization induced new cytotoxic responses while proteins appeared to efficiently boost previous responses. One HIV-1 subtype B antigen was strongly immunogenic in a human immunotherapeutic trial and permitted better survival at 2 years of the study in patients with poor prognosis.

Original language	English
Pages (from-to)	1988-1993
Number of pages	6
Journal	Vaccine
Volume	20
Issue number	15
DOIs	https://doi.org/10.1016/S0264-410X(02)00084-1
Publication status	Published - May 6 2002

Keywords

HIV
HIV subtypes
Immunization

ASJC Scopus subject areas

Immunology
Microbiology
Virology
Infectious Diseases
Public Health, Environmental and Occupational Health
veterinary(all)

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HIV subtypes and recombination strains-strategies for induction of immune responses in man. / Wahren, B.; Ljungberg, K.; Rollman, E.; Levi, M.; Zuber, B.; Kjerrström Zuber, A.; Hinkula, J.; Leandersson, A. C.; Calarota, S.; Hejdeman, B.; Bratt, G.; Sandström, E.

In: Vaccine, Vol. 20, No. 15, 06.05.2002, p. 1988-1993.

Research output: Contribution to journal › Article › peer-review

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AU - Wahren, B.

AU - Ljungberg, K.

AU - Rollman, E.

AU - Levi, M.

AU - Zuber, B.

AU - Kjerrström Zuber, A.

AU - Hinkula, J.

AU - Leandersson, A. C.

AU - Calarota, S.

AU - Hejdeman, B.

AU - Bratt, G.

AU - Sandström, E.

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AB - Clinical and experimental studies of HIV-1 subcomponents were made in order to increase their immunogenicity. HIV subtype envelopes A, B and C have been compared and a detailed analysis made by peptides of the coreceptor-ligand interactions. We identified a direct interaction between HIV-1 envelope and a cellular receptor at the amino acid level. Both the viral subtype and its tropism appeared to influence inhibition of infection. Genetic immunization induced new cytotoxic responses while proteins appeared to efficiently boost previous responses. One HIV-1 subtype B antigen was strongly immunogenic in a human immunotherapeutic trial and permitted better survival at 2 years of the study in patients with poor prognosis.

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KW - HIV subtypes

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HIV subtypes and recombination strains-strategies for induction of immune responses in man

Abstract

Keywords

ASJC Scopus subject areas

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