Abstract
The human immunodeficiency virus (HIV-1) (transactivator of transcription (Tat)) protein is a pleiotropic factor that induces a broad range of biological effects in numerous cell types. At the HIV promoter, Tat is a powerful transactivator of gene expression, which acts by both inducing chromatin remodeling and by recruiting elongation-competent transcriptional complexes onto the viral LTR. Besides these transcriptional activities, Tat is released outside the cells and interacts with different cell membrane-associated receptors. Finally, extracellular Tat can be internalized by cells through an active endocytosis process. Here we discuss some of the molecular mechanisms involved in intracellular and extracellular Tat function.
| Original language | English |
|---|---|
| Pages (from-to) | 57-65 |
| Number of pages | 9 |
| Journal | FEMS Microbiology Letters |
| Volume | 220 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Mar 14 2003 |
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Keywords
- Human immunodeficiency virus
- Lambda phage
- Pathogenesis
- Transactivation
- Transactivator of transcription
ASJC Scopus subject areas
- Genetics
- Molecular Biology
- Applied Microbiology and Biotechnology
- Microbiology
Cite this
HIV Tat, its TARgets and the control of viral gene expression. / Brigati, Claudio; Giacca, Mauro; Noonan, Douglas M.; Albini, Adriana.
In: FEMS Microbiology Letters, Vol. 220, No. 1, 14.03.2003, p. 57-65.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - HIV Tat, its TARgets and the control of viral gene expression
AU - Brigati, Claudio
AU - Giacca, Mauro
AU - Noonan, Douglas M.
AU - Albini, Adriana
PY - 2003/3/14
Y1 - 2003/3/14
N2 - The human immunodeficiency virus (HIV-1) (transactivator of transcription (Tat)) protein is a pleiotropic factor that induces a broad range of biological effects in numerous cell types. At the HIV promoter, Tat is a powerful transactivator of gene expression, which acts by both inducing chromatin remodeling and by recruiting elongation-competent transcriptional complexes onto the viral LTR. Besides these transcriptional activities, Tat is released outside the cells and interacts with different cell membrane-associated receptors. Finally, extracellular Tat can be internalized by cells through an active endocytosis process. Here we discuss some of the molecular mechanisms involved in intracellular and extracellular Tat function.
AB - The human immunodeficiency virus (HIV-1) (transactivator of transcription (Tat)) protein is a pleiotropic factor that induces a broad range of biological effects in numerous cell types. At the HIV promoter, Tat is a powerful transactivator of gene expression, which acts by both inducing chromatin remodeling and by recruiting elongation-competent transcriptional complexes onto the viral LTR. Besides these transcriptional activities, Tat is released outside the cells and interacts with different cell membrane-associated receptors. Finally, extracellular Tat can be internalized by cells through an active endocytosis process. Here we discuss some of the molecular mechanisms involved in intracellular and extracellular Tat function.
KW - Human immunodeficiency virus
KW - Lambda phage
KW - Pathogenesis
KW - Transactivation
KW - Transactivator of transcription
UR - http://www.scopus.com/inward/record.url?scp=0348087031&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0348087031&partnerID=8YFLogxK
U2 - 10.1016/S0378-1097(03)00067-3
DO - 10.1016/S0378-1097(03)00067-3
M3 - Article
C2 - 12644228
AN - SCOPUS:0348087031
VL - 220
SP - 57
EP - 65
JO - FEMS Microbiology Letters
JF - FEMS Microbiology Letters
SN - 0378-1097
IS - 1
ER -