HIV Tat, its TARgets and the control of viral gene expression

Claudio Brigati, Mauro Giacca, Douglas M. Noonan, Adriana Albini

Research output: Contribution to journalArticlepeer-review

Abstract

The human immunodeficiency virus (HIV-1) (transactivator of transcription (Tat)) protein is a pleiotropic factor that induces a broad range of biological effects in numerous cell types. At the HIV promoter, Tat is a powerful transactivator of gene expression, which acts by both inducing chromatin remodeling and by recruiting elongation-competent transcriptional complexes onto the viral LTR. Besides these transcriptional activities, Tat is released outside the cells and interacts with different cell membrane-associated receptors. Finally, extracellular Tat can be internalized by cells through an active endocytosis process. Here we discuss some of the molecular mechanisms involved in intracellular and extracellular Tat function.

Original languageEnglish
Pages (from-to)57-65
Number of pages9
JournalFEMS Microbiology Letters
Volume220
Issue number1
DOIs
Publication statusPublished - Mar 14 2003

Keywords

  • Human immunodeficiency virus
  • Lambda phage
  • Pathogenesis
  • Transactivation
  • Transactivator of transcription

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Microbiology

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