HIV therapeutic vaccines aimed at intensifying combination antiretroviral therapy

Sonia Moretti, Aurelio Cafaro, Antonella Tripiciano, Orietta Picconi, Stefano Buttò, Fabrizio Ensoli, Cecilia Sgadari, Paolo Monini, Barbara Ensoli

Research output: Contribution to journalReview articlepeer-review

Abstract

Introduction: Although successful at suppressing HIV replication, combination antiretroviral therapy (cART) only partially restores immune functions and fails to reduce the latent HIV reservoir, thus requiring novel interventions for its intensification. Areas covered: Here are reviewed therapeutic vaccine candidates that are being developed to this goal. Among them, the Tat vaccine has been shown to promote immune restoration, including CD4+ T-cell recovery in low immunological responders, and to reduce the virus reservoirs well beyond what achieved with long-term suppressive cART. Expert opinion: The authors propose the Tat vaccine as a promising vaccine candidate for cART intensification toward HIV reservoirs depletion, functional cure, and eradication strategies, suggesting that targeting a key protein in the virus life cycle is pivotal to success.

Original languageEnglish
Pages (from-to)71-84
Number of pages14
JournalExpert Review of Vaccines
Volume19
Issue number1
DOIs
Publication statusPublished - Jan 2 2020

Keywords

  • anti-Tat antibodies
  • cART intensification
  • clinical trials
  • functional cure
  • HIV reservoir
  • HIV-1 Tat
  • HIV-1 therapeutic vaccine
  • immune system restoration
  • immunotherapy
  • proviral DNA

ASJC Scopus subject areas

  • Immunology
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

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