TY - JOUR
T1 - HLA-A, B, C, DR and DQ expression and hepatocellular carcinoma
T2 - study of 205 Italian subjects
AU - Ricci, Giorgio
AU - Colombo, Clara
AU - Ghiazza, Barbara
AU - Porta, Camillo
AU - Moroni, Mauro
AU - Illeni, Maria Teresa
PY - 1995/11/27
Y1 - 1995/11/27
N2 - We have evaluated the frequency of HLA class I and II antigens in 205 Italian patients with hepatocellular carcinoma (HCC) and 749 blood donors (controls). Moreover we have looked for correlations between HLA antigen frequencies and HBV and/or HCV infections in HCC patients. We found great differences in HLA antigen frequencies considering only two groups: HCC patients and controls. The polymorphism is smaller when we consider the different groups of HCC patients in regard to the previous viral infections (HBV and/or HCV). The most interesting finding is the higher frequency of Cw7, B8 and DR3 in almost all groups of HCC patients. It is well known, that the HLA A1, Cw7, B8, DR3 antigen haplotype is associated with a rapid decline of CD4 cells, and HLA B8, DR3 positive subjects may display some changes in immune parameters and are prone to develop several immunological diseases. Thus HCC might be the result of a lower sensitivity (genetically given) to mitogenic stimuli of HBV and HCV.
AB - We have evaluated the frequency of HLA class I and II antigens in 205 Italian patients with hepatocellular carcinoma (HCC) and 749 blood donors (controls). Moreover we have looked for correlations between HLA antigen frequencies and HBV and/or HCV infections in HCC patients. We found great differences in HLA antigen frequencies considering only two groups: HCC patients and controls. The polymorphism is smaller when we consider the different groups of HCC patients in regard to the previous viral infections (HBV and/or HCV). The most interesting finding is the higher frequency of Cw7, B8 and DR3 in almost all groups of HCC patients. It is well known, that the HLA A1, Cw7, B8, DR3 antigen haplotype is associated with a rapid decline of CD4 cells, and HLA B8, DR3 positive subjects may display some changes in immune parameters and are prone to develop several immunological diseases. Thus HCC might be the result of a lower sensitivity (genetically given) to mitogenic stimuli of HBV and HCV.
KW - Hepatitis B virus
KW - Hepatitis C virus
KW - Hepatocellular carcinoma
KW - HLA
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U2 - 10.1016/S0304-3835(06)80020-0
DO - 10.1016/S0304-3835(06)80020-0
M3 - Article
C2 - 8529200
AN - SCOPUS:0028819701
VL - 98
SP - 121
EP - 125
JO - Cancer Letters
JF - Cancer Letters
SN - 0304-3835
IS - 1
ER -