HLA and immunoglobulin polymorphisms in idiopathic dilated cardiomyopathy

Miryam Martinetti, Jean Michel Dogoujon, Alida L P Caforio, Giselle Schwarz, Antonello Gavazzi, Gabriella Graziano, Eloisa Arbustini, Renata Lorini, William J. McKenna, Gian Franco Bottazzo, Mariaclara Cuccia

Research output: Contribution to journalArticle

Abstract

Dilated cardiomyopathy (DCM) is an idiopathic heart muscle disorder. The presence of circulating cardiac antibodies and the association with HLA-DR4 are consistent with autoimmune pathogenesis in a subset of patients. Sixty-eight DCM patients and 277 controls were typed for IgG heavy-chain constant region (Gm) and κ light-chain (Km) allotypes. All patients and 210 of the 277 controls were HLA-DR typed. The Gm (1, 3, 17; 23; 5*, 21, 28) phenotype was overrepresented in DCM compared with controls (25% vs 13%, p = 0.0139, Pc = NS, RR = 2.23). The frequency of this phenotype was higher in patients with younger age at onset, shorter symptom duration, and among those who were positive for cardiac as well as for non-organ-specific autoantibodies than in controls. A higher frequency of the Gm (1,± 2, 3, 17; ± 23; 5*, 21, 28) heterozygous phenotypes was also found in DCM compared to controls (40.91% vs 26389%; p = 0.02, pc = 0.04, RR = 1.88). The finding of Gm heterozygosity in DCM was associated with serum positivity for cardiac antibodies. A higher proportion of DCM patients were positive for both the Gm (1, 3, 17; 23; 5*, 21, 28) phenotype and HLA-DR4 compared to normals (3/68 vs 0/210; p = 0.04, RR = 22.50). A potentiating interactive effect in susceptibility to DCM was also found between the Gm (1, ±2, 3, 17; ±23; 5*, 21, 28) heterozygous phenotypes and HLA-DR4 (7/66 vs 2/207, p = 0.0009, RR = 12.16). These Gm phenotypes may be new markers of susceptibility in DCM, associated with positive autoimmune serology. The potentiating interaction of Gm and HLA-DR4 is in keeping with results reported in other autoimmune diseases.

Original languageEnglish
Pages (from-to)193-199
Number of pages7
JournalHuman Immunology
Volume35
Issue number3
DOIs
Publication statusPublished - 1992

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Dilated Cardiomyopathy
Immunoglobulins
HLA-DR4 Antigen
Phenotype
Immunoglobulin Km Allotypes
Antibodies
HLA-DR Antigens
Muscular Diseases
Serology
Age of Onset
Autoantibodies
Autoimmune Diseases
Myocardium
Immunoglobulin G
Light
Serum

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Martinetti, M., Dogoujon, J. M., Caforio, A. L. P., Schwarz, G., Gavazzi, A., Graziano, G., ... Cuccia, M. (1992). HLA and immunoglobulin polymorphisms in idiopathic dilated cardiomyopathy. Human Immunology, 35(3), 193-199. https://doi.org/10.1016/0198-8859(92)90105-V

HLA and immunoglobulin polymorphisms in idiopathic dilated cardiomyopathy. / Martinetti, Miryam; Dogoujon, Jean Michel; Caforio, Alida L P; Schwarz, Giselle; Gavazzi, Antonello; Graziano, Gabriella; Arbustini, Eloisa; Lorini, Renata; McKenna, William J.; Bottazzo, Gian Franco; Cuccia, Mariaclara.

In: Human Immunology, Vol. 35, No. 3, 1992, p. 193-199.

Research output: Contribution to journalArticle

Martinetti, M, Dogoujon, JM, Caforio, ALP, Schwarz, G, Gavazzi, A, Graziano, G, Arbustini, E, Lorini, R, McKenna, WJ, Bottazzo, GF & Cuccia, M 1992, 'HLA and immunoglobulin polymorphisms in idiopathic dilated cardiomyopathy', Human Immunology, vol. 35, no. 3, pp. 193-199. https://doi.org/10.1016/0198-8859(92)90105-V
Martinetti M, Dogoujon JM, Caforio ALP, Schwarz G, Gavazzi A, Graziano G et al. HLA and immunoglobulin polymorphisms in idiopathic dilated cardiomyopathy. Human Immunology. 1992;35(3):193-199. https://doi.org/10.1016/0198-8859(92)90105-V
Martinetti, Miryam ; Dogoujon, Jean Michel ; Caforio, Alida L P ; Schwarz, Giselle ; Gavazzi, Antonello ; Graziano, Gabriella ; Arbustini, Eloisa ; Lorini, Renata ; McKenna, William J. ; Bottazzo, Gian Franco ; Cuccia, Mariaclara. / HLA and immunoglobulin polymorphisms in idiopathic dilated cardiomyopathy. In: Human Immunology. 1992 ; Vol. 35, No. 3. pp. 193-199.
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abstract = "Dilated cardiomyopathy (DCM) is an idiopathic heart muscle disorder. The presence of circulating cardiac antibodies and the association with HLA-DR4 are consistent with autoimmune pathogenesis in a subset of patients. Sixty-eight DCM patients and 277 controls were typed for IgG heavy-chain constant region (Gm) and κ light-chain (Km) allotypes. All patients and 210 of the 277 controls were HLA-DR typed. The Gm (1, 3, 17; 23; 5*, 21, 28) phenotype was overrepresented in DCM compared with controls (25{\%} vs 13{\%}, p = 0.0139, Pc = NS, RR = 2.23). The frequency of this phenotype was higher in patients with younger age at onset, shorter symptom duration, and among those who were positive for cardiac as well as for non-organ-specific autoantibodies than in controls. A higher frequency of the Gm (1,± 2, 3, 17; ± 23; 5*, 21, 28) heterozygous phenotypes was also found in DCM compared to controls (40.91{\%} vs 26389{\%}; p = 0.02, pc = 0.04, RR = 1.88). The finding of Gm heterozygosity in DCM was associated with serum positivity for cardiac antibodies. A higher proportion of DCM patients were positive for both the Gm (1, 3, 17; 23; 5*, 21, 28) phenotype and HLA-DR4 compared to normals (3/68 vs 0/210; p = 0.04, RR = 22.50). A potentiating interactive effect in susceptibility to DCM was also found between the Gm (1, ±2, 3, 17; ±23; 5*, 21, 28) heterozygous phenotypes and HLA-DR4 (7/66 vs 2/207, p = 0.0009, RR = 12.16). These Gm phenotypes may be new markers of susceptibility in DCM, associated with positive autoimmune serology. The potentiating interaction of Gm and HLA-DR4 is in keeping with results reported in other autoimmune diseases.",
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AU - Arbustini, Eloisa

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