HLA and multiple sclerosis in Italy: a review of the literature

L. La Mantia, M. T. Illeni, C. Milanese, A. Salmaggi, M. Eoli, G. Pellegris, A. Nespolo

Research output: Contribution to journalArticlepeer-review

Abstract

HLA antigens of locus A, C, B, DR and DQ were typed in 104 Italian multiple sclerosis patients and in 905 healthy controls; the results have been compared with those published in the Italian literature. The Italian studies have been reviewed regarding the ethnic origin of the typed population and the corresponding prevalence of the disease. The data suggest a lack of association between A3 and B7 antigens and Italian multiple sclerosis and a relevance of other DR locus antigens (mainly DR4 and DR5), in addition to DR2, in the susceptibility to the disease.

Original languageEnglish
Pages (from-to)441-444
Number of pages4
JournalJournal of Neurology
Volume237
Issue number7
DOIs
Publication statusPublished - Nov 1990

Keywords

  • HLA
  • Italy
  • Multiple sclerosis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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