ANTIGENI DI ISTOCOMPATIBILITA (HLA) ED IMMUNITA CELLULARE NEL DIABETE MELLITO

Translated title of the contribution: HLA antigen and cell immunity in diabetes mellitus

V. Saibene, M. T. Illeni, A. Margonato

Research output: Contribution to journalArticlepeer-review

Abstract

HLA-antigens have been Typed in 67 insulin-dependent diabetics (IDD) and in 730 normal subjects. IDD show a significant increase in HLA-B8, while no difference has been found for BW15, B7 and CW frequencies. Cellmediated immunity has been evaluated by E-rosette forming ability of peripheral lymphocytes. IDD present a reduced ERFA versus non insulin-dependent diabetics and normal subjects without relationship with HLA-B8. In vitro incubation with insulin of IDD lymphocytes improves ERFA, while glucagon depresses ERFA from normal lymphocytes. According to these data, the endocrine enbalancement of IDD might affect CMI apart from genetical control of immune response by HLA system.

Translated title of the contributionHLA antigen and cell immunity in diabetes mellitus
Original languageItalian
Pages (from-to)291-296
Number of pages6
JournalMinerva Dietologica e Gastroenterologica
Volume25
Issue number3
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Medicine(all)

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