HLA antigens and the reactivity of lymphocytes to some drugs and PHA

R. Scorza-Smeraldi, M. G. Sabbadini Villa, G. Fabio, P. Bonara, M. Vanoli, L. Resele, C. Zanussi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Peripheral blood lymphocytes from 15 healthy subjects, selected on the basis of their HLA types, were cultured in vitro in the presence of PHA and of a number of drugs which bind adrenergic or dopaminergic receptors (dopamine, norepinephrine, chlorpromazine, haloperidol, propranolol and apomorphine). The results obtained are consistent with an interference between HLA-A1 and cross-reacting specificities and the effect explained by these drugs on the lymphocyte activation by PHA. The possibility is suggested that HLA-A1 and cross-reacting antigens interfere with the binding of such drugs to the cell membrane receptors.

Original languageEnglish
Pages (from-to)145-149
Number of pages5
JournalInternational Journal of Immunopharmacology
Volume5
Issue number2
DOIs
Publication statusPublished - 1983

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HLA Antigens
HLA-A1 Antigen
Lymphocytes
Pharmaceutical Preparations
Apomorphine
Chlorpromazine
Dopamine Receptors
Haloperidol
Lymphocyte Activation
Propranolol
Adrenergic Agents
Adrenergic Receptors
Healthy Volunteers
Cell Membrane
Antigens

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Cite this

Scorza-Smeraldi, R., Sabbadini Villa, M. G., Fabio, G., Bonara, P., Vanoli, M., Resele, L., & Zanussi, C. (1983). HLA antigens and the reactivity of lymphocytes to some drugs and PHA. International Journal of Immunopharmacology, 5(2), 145-149. https://doi.org/10.1016/0192-0561(83)90006-1

HLA antigens and the reactivity of lymphocytes to some drugs and PHA. / Scorza-Smeraldi, R.; Sabbadini Villa, M. G.; Fabio, G.; Bonara, P.; Vanoli, M.; Resele, L.; Zanussi, C.

In: International Journal of Immunopharmacology, Vol. 5, No. 2, 1983, p. 145-149.

Research output: Contribution to journalArticle

Scorza-Smeraldi, R, Sabbadini Villa, MG, Fabio, G, Bonara, P, Vanoli, M, Resele, L & Zanussi, C 1983, 'HLA antigens and the reactivity of lymphocytes to some drugs and PHA', International Journal of Immunopharmacology, vol. 5, no. 2, pp. 145-149. https://doi.org/10.1016/0192-0561(83)90006-1
Scorza-Smeraldi R, Sabbadini Villa MG, Fabio G, Bonara P, Vanoli M, Resele L et al. HLA antigens and the reactivity of lymphocytes to some drugs and PHA. International Journal of Immunopharmacology. 1983;5(2):145-149. https://doi.org/10.1016/0192-0561(83)90006-1
Scorza-Smeraldi, R. ; Sabbadini Villa, M. G. ; Fabio, G. ; Bonara, P. ; Vanoli, M. ; Resele, L. ; Zanussi, C. / HLA antigens and the reactivity of lymphocytes to some drugs and PHA. In: International Journal of Immunopharmacology. 1983 ; Vol. 5, No. 2. pp. 145-149.
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