Abstract
Peripheral blood lymphocytes from 15 healthy subjects, selected on the basis of their HLA types, were cultured in vitro in the presence of PHA and of a number of drugs which bind adrenergic or dopaminergic receptors (dopamine, norepinephrine, chlorpromazine, haloperidol, propranolol and apomorphine). The results obtained are consistent with an interference between HLA-A1 and cross-reacting specificities and the effect explained by these drugs on the lymphocyte activation by PHA. The possibility is suggested that HLA-A1 and cross-reacting antigens interfere with the binding of such drugs to the cell membrane receptors.
| Original language | English |
|---|---|
| Pages (from-to) | 145-149 |
| Number of pages | 5 |
| Journal | International Journal of Immunopharmacology |
| Volume | 5 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1983 |
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ASJC Scopus subject areas
- Immunology
- Pharmacology
Cite this
HLA antigens and the reactivity of lymphocytes to some drugs and PHA. / Scorza-Smeraldi, R.; Sabbadini Villa, M. G.; Fabio, G.; Bonara, P.; Vanoli, M.; Resele, L.; Zanussi, C.
In: International Journal of Immunopharmacology, Vol. 5, No. 2, 1983, p. 145-149.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - HLA antigens and the reactivity of lymphocytes to some drugs and PHA
AU - Scorza-Smeraldi, R.
AU - Sabbadini Villa, M. G.
AU - Fabio, G.
AU - Bonara, P.
AU - Vanoli, M.
AU - Resele, L.
AU - Zanussi, C.
PY - 1983
Y1 - 1983
N2 - Peripheral blood lymphocytes from 15 healthy subjects, selected on the basis of their HLA types, were cultured in vitro in the presence of PHA and of a number of drugs which bind adrenergic or dopaminergic receptors (dopamine, norepinephrine, chlorpromazine, haloperidol, propranolol and apomorphine). The results obtained are consistent with an interference between HLA-A1 and cross-reacting specificities and the effect explained by these drugs on the lymphocyte activation by PHA. The possibility is suggested that HLA-A1 and cross-reacting antigens interfere with the binding of such drugs to the cell membrane receptors.
AB - Peripheral blood lymphocytes from 15 healthy subjects, selected on the basis of their HLA types, were cultured in vitro in the presence of PHA and of a number of drugs which bind adrenergic or dopaminergic receptors (dopamine, norepinephrine, chlorpromazine, haloperidol, propranolol and apomorphine). The results obtained are consistent with an interference between HLA-A1 and cross-reacting specificities and the effect explained by these drugs on the lymphocyte activation by PHA. The possibility is suggested that HLA-A1 and cross-reacting antigens interfere with the binding of such drugs to the cell membrane receptors.
UR - http://www.scopus.com/inward/record.url?scp=0020611493&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020611493&partnerID=8YFLogxK
U2 - 10.1016/0192-0561(83)90006-1
DO - 10.1016/0192-0561(83)90006-1
M3 - Article
C2 - 6603432
AN - SCOPUS:0020611493
VL - 5
SP - 145
EP - 149
JO - International Journal of Immunopharmacology
JF - International Journal of Immunopharmacology
SN - 0192-0561
IS - 2
ER -