HLA antigen phenotypes were studied in 53 patients with ulcerative colitis and two healthy, randomly selected, populations. The first control group consisted of 269 subjects of Abruzzo and Emilia (Italy) origin, like the patients; the second was a European Caucasian panel of 347 individuals. No statistically significant difference in the frequency of each antigen was noted between the three groups. In addition, neither the frequency, nor the degree of linkage disequilibrium of the haplotypes most frequently found in the patients, was significantly different from that found in the controls. The presence in a single patient of the phenotype HLA-B27, and the absence of ankylosing spondylitis, in contrast with other authors' findings was noteworthy. Findings suggest that studies on the relationship between histocompatibility antigens and ulcerative colitis must take into consideration the possible involvement of other genes and the heterogeneity of the disease.
|Number of pages||3|
|Journal||Italian Journal of Gastroenterology|
|Publication status||Published - 1978|
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