HLA antigens in insulin-dependent diabetes: Their role on development of remission phase and degenerative complications of diabetes

A. Secchi, G. Fabio, A. E. Pontiroli, N. B. Eisera, L. Ferrua, G. Pozza, R. Scorza

Research output: Contribution to journalArticlepeer-review

Abstract

In this study we investigated the association between HLA-A, B, C and DR antigens and the susceptibility to insulin-dpendent (Type I) diabetes (IDDM) in a sample of 69 Italian patients. The association with the same relevant clinical parameters (familial aggregation, age at onset, remission, macroangiopathy, microangiopathy and neuropathy) were further evaluated. In our patients HLA-DR3 and DR4 phenotypes were significantly increased while DR2 and DR5 phenotypes were decreased when compared to the Italian population. Remission was positively associated with DR2 and negatively associated DR4. DR4 and DR5 were significantly associated with retinopathy and nephropathy, respectively. DR5 was also significantly increased in patients with a co-occurrence of both retinopathy and nephropathy and in patients in which neuropathy, nephropathy and retinopathy were concomitant. Our results suggest that different HLA or linked genes, known to influence the immune response by different mechanisms, can interact in influencing the susceptibility to IDDM and that specific HLA-DR factors may be more involved in determining peculiar clinical features of the disease.

Original languageEnglish
Pages (from-to)3-9
Number of pages7
JournalDiabetes, Nutrition and Metabolism - Clinical and Experimental
Volume2
Issue number1
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Food Science
  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Fingerprint

Dive into the research topics of 'HLA antigens in insulin-dependent diabetes: Their role on development of remission phase and degenerative complications of diabetes'. Together they form a unique fingerprint.

Cite this